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  4. Recombinant Human T-complex protein 10A homolog 2 (TCP10L)

Recombinant Human T-complex protein 10A homolog 2 (TCP10L)

  • 中文名称：
    人TCP10L重组蛋白
  • 货号：
    CSB-YP823465HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TCP10L重组蛋白
  • 货号：
    CSB-EP823465HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TCP10L重组蛋白
  • 货号：
    CSB-EP823465HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TCP10L重组蛋白
  • 货号：
    CSB-BP823465HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TCP10L重组蛋白
  • 货号：
    CSB-MP823465HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TCP10L
  • Uniprot No.：
  • 别名：
    TCP10L; PRED77; T-complex protein 10A homolog 1; T-complex protein 10A-1; TCP10A-1; TCP10-like
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-215
  • 氨基酸序列
    MLAGQLEARD PKEGTHPEDP CPGAGAVMEK TAVAAEVLTE DCNTGEMPPL QQQIIRLHQE LGRQKSLWAD VHGKLRSHID ALREQNMELR EKLRALQLQR WKARKKSAAS PHAGQESHTL ALEPAFGKIS PLSADEETIP KYAGHKNQSA TLLGQRSSSN NSAPPKPMSL KIERISSWKT PPQENRDKNL SRRRQDRRAT PTGRPTPCAE RRGGV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.
  • 基因功能参考文献：
    1. TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression. PMID: 26698869
    2. Overexpression of TCP10L in hepatocellular carcinoma cells suppressed colony formation, inhibited cell cycle progression through G0/G1 phase, and attenuated cell growth in vivo. PMID: 24565846
    3. The result revealed that TCP10L expressed specifically in the human liver and testis PMID: 14586771
    4. Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells. PMID: 15469726
    5. The specific expression pattern of TCP10L and interaction with DAPK-3 implies that TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3. PMID: 15910542

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TCP10 family
  • 组织特异性：
    Expressed in liver and testis. Expressed in the seminiferous tubules (at protein level).
  • 数据库链接：

    HGNC: 11657

    OMIM: 608365

    KEGG: hsa:140290

    STRING: 9606.ENSP00000300258

    UniGene: Hs.728804