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TCF12 Antibody

  • 货号：
    CSB-PA023293ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA023293ESR1HU at dilution of 1:100
    • Immunoprecipitating TCF12 in Jurkat whole cell lysate
      Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA023293ESR1HU in Jurkat whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA023293ESR1HU (4μg) + Jurkat whole cell lysate (500μg)
      Lane 3: Jurkat whole cell lysate (20μg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TCF12 Polyclonal antibody
  • Uniprot No.：
    Q99081
  • 基因名：
  • 别名：
    bHLHb20 antibody; Class B basic helix-loop-helix protein 20 antibody; DNA binding protein HTF4 antibody; DNA-binding protein HTF4 antibody; E box binding protein antibody; E-box-binding protein antibody; HEB antibody; Helix loop helix transcription factor 4 antibody; HsT17266 antibody; HTF4 antibody; HTF4_HUMAN antibody; TCF-12 antibody; Tcf12 antibody; Transcription factor 12 antibody; Transcription factor HTF-4 antibody; Transcription factor HTF4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transcription factor 12 protein (443-682AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
  • 基因功能参考文献：
    1. These results identify HEB as a critical regulator of human mesodermal and hematopoietic specification. PMID: 28803914
    2. HDAC1 promoted migration and invasion of gallbladder tumor cells by binding with TCF12 to promote epithelial mesenchymal transformation. PMID: 27092878
    3. Study describes the identification of three large inherited intragenic exon deletions in TCF12 using whole-genome sequencing and one large inherited duplication using targeted TCF12 sequencing in patients with craniosynostosis. PMID: 27158814
    4. Heb expression is regulated by Med19 in breast cancer cells. PMID: 27572702
    5. enforced expression of transcription factor 12 suppressed cell proliferation, migration, and invasion in vitro and inhibited tumor growth in vivo. In conclusion, transcription factor 12 protein may be a novel molecule which plays a critical role in prostate cancer progression and patients' prognosis, suggesting it might be a promising therapeutic target for prostate cancer therapy PMID: 28651494
    6. HEB may be involved in GBM cell proliferation, as HEB silencing reduced proliferation in cells cultured as monolayers or neurospheres. Furthermore, the results suggested a potential role for HEB in the maintenance of GBM stem cells, as HEB silencing affected the differentiation capacity of cells. PMID: 27779678
    7. Two novel translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12 in myeloid leukemia. PMID: 26671595
    8. Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing. PMID: 25271085
    9. show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type PMID: 26068201
    10. several familial cases of coronal synostosis associated with mutations in TCF12 PMID: 24736737
    11. haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1. PMID: 23354436
    12. the CD91/IKK/NF-kappaB signaling cascade is involved in secreted HSP90alpha-induced TCF12 expression, leading to E-cadherin down-regulation and enhanced CRC cell migration/invasion PMID: 23386606
    13. TCF12 functioned as a transcriptional repressor of E-cadherin and its overexpression was significantly correlated with the occurrence of CRC metastasis. PMID: 22130667
    14. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint. PMID: 20798984
    15. T cell development is impaired by Id2, most likely by sequestering HEB, whereas NK cell development is promoted by increasing a pool of CD1a-CD5+ NK cell progenitors, which together with IL-15 differentiate into mature NK cells PMID: 20483740
    16. two alternative acceptor sites for mRNA splicing yield two distinguishable transcripts (HTF4a and HTF4b) which differ in their 5' untranslated region but share identical coding sequences. PMID: 12826747
    17. CBFA2T3 interacts with ZNF652 to repress HEB expression, and in addition CBFA2T3 interacts with the HEB protein to inhibit its activator function. PMID: 18456661
    18. The DNA binding profile of the E-protein HEB was grossly rearranged upon expression of AML1/ETO, and the fusion protein was found to co-localize with both AML1 and HEB on many of its regulated targets PMID: 19043539

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  • 相关疾病：
    Craniosynostosis 3 (CRS3)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line.
  • 数据库链接：

    HGNC: 11623

    OMIM: 600480

    KEGG: hsa:6938

    STRING: 9606.ENSP00000331057

    UniGene: Hs.511504