TCF12
TCF12，即转录因子12，别名HEB、p64、CRS3、HH26、HTF4、TCF-12、bHLHb20、HsT17266等。TCF12是一种基本螺旋-环-螺旋(bHLH) E蛋白家族成员，能够识别特定的结合位点(E-box)"CANNTG"。它在多种组织中表达，包括骨骼肌、胸腺、B细胞和T细胞，可能通过与其他bHLH E蛋白形成异二聚体来参与调节谱系特异性基因表达。TCF12在生物学上的意义非常广泛，它参与调控多种细胞的发育和分化过程。例如，TCF12在造血干细胞中高表达，对调节其功能和向淋巴细胞前体分化中起着重要作用。此外，TCF12还与颅骨生长和运动学习相关，其功能丧失突变可导致颅缝早闭和神经发育迟缓。在骨关节炎中，TCF12通过靶向CXCR4调节TGF-β/Smad2/3信号通路，加速疾病进展。因此，TCF12在维持正常生理功能和疾病发生发展中扮演着关键角色。
热销产品
TCF12 Antibody (CSB-PA023293ESR1HU)
验证数据
Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA023293ESR1HU at dilution of 1:100
Immunoprecipitating TCF12 in Jurkat whole cell lysate
Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA023293ESR1HU in Jurkat whole cell lysate.
For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: CSB-PA023293ESR1HU (4μg) + Jurkat whole cell lysate (500μg)
Lane 3: Jurkat whole cell lysate (20μg)
TCF12 Antibodies
TCF12 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA023293GA01HU | TCF12 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA023293ESR1HU | TCF12 Antibody | Human | ELISA, IHC, IP |
TCF12 Proteins
TCF12 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023293CH CSB-EP023293CH CSB-BP023293CH CSB-MP023293CH CSB-EP023293CH-B |
Recombinant Chicken Transcription factor 12 (TCF12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF12 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023293RA CSB-EP023293RA CSB-BP023293RA CSB-MP023293RA CSB-EP023293RA-B |
Recombinant Rat Transcription factor 12 (Tcf12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF12 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023293MO CSB-EP023293MO CSB-BP023293MO CSB-MP023293MO CSB-EP023293MO-B |
Recombinant Mouse Transcription factor 12 (Tcf12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF12 Proteins for Mesocricetus auratus (Golden hamster)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023293MRG CSB-EP023293MRG CSB-BP023293MRG CSB-MP023293MRG CSB-EP023293MRG-B |
Recombinant Mesocricetus auratus Transcription factor 12 (TCF12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF12 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023293HU CSB-EP023293HU CSB-BP023293HU CSB-MP023293HU CSB-EP023293HU-B |
Recombinant Human Transcription factor 12 (TCF12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF12 Proteins for Papio hamadryas (Hamadryas baboon)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023293ERJ CSB-EP023293ERJ CSB-BP023293ERJ CSB-MP023293ERJ CSB-EP023293ERJ-B |
Recombinant Papio hamadryas Transcription factor 12 (TCF12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
