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STYX Antibody

  • 货号：
    CSB-PA851966LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, 293T whole cell lysate, HL60 whole cell lysate
      All lanes: STYX antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STYX Polyclonal antibody
  • Uniprot No.：
    Q8WUJ0
  • 基因名：
    STYX
  • 别名：
    Protein tyrosine phosphatase like protein antibody; Protein tyrosine phosphatase-like protein antibody; Serine/threonine/tyrosine interacting protein antibody; Serine/threonine/tyrosine-interacting protein antibody; Styx antibody; STYX_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine/tyrosine-interacting protein (1-223AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，STYX Antibody (CSB-PA851966LA01HU)，的标记方式是Non-conjugated。对于STYX Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA851966LB01HU STYX Antibody, HRP conjugated ELISA
    FITC CSB-PA851966LC01HU STYX Antibody, FITC conjugated
    Biotin CSB-PA851966LD01HU STYX Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis.
  • 基因功能参考文献：
    1. The s show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex. PMID: 28007894
    2. Results suggest that STYX is a pseudophosphatase that uses the 'competitor' and 'anchor' mode of action to exert its biologic roles. [review] PMID: 28408485
    3. results identify STYX as an important regulator of ERK1/2 signaling critical for cell migration PMID: 23847209
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 数据库链接：

    HGNC: 11447

    OMIM: 615814

    KEGG: hsa:6815

    STRING: 9606.ENSP00000346599

    UniGene: Hs.364980