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  4. Recombinant Human Serine/threonine/tyrosine-interacting protein (STYX)

Recombinant Human Serine/threonine/tyrosine-interacting protein (STYX)

  • 货号：
    CSB-YP851966HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP851966HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP851966HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP851966HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP851966HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    STYX
  • Uniprot No.：
  • 别名：
    Protein tyrosine phosphatase like protein ; Protein tyrosine phosphatase-like protein; Serine/threonine/tyrosine interacting protein; Serine/threonine/tyrosine-interacting protein; Styx; STYX_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-223
  • 氨基酸序列
    MEDVKLEFPS LPQCKEDAEE WTYPMRREMQ EILPGLFLGP YSSAMKSKLP VLQKHGITHI ICIRQNIEAN FIKPNFQQLF RYLVLDIADN PVENIIRFFP MTKEFIDGSL QMGGKVLVHG NAGISRSAAF VIAYIMETFG MKYRDAFAYV QERRFCINPN AGFVHQLQEY EAIYLAKLTI QMMSPLQIER SLSVHSGTTG SLKRTHEEED DFGTMQVATA QNG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis.
  • 基因功能参考文献：
    1. The s show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex. PMID: 28007894
    2. Results suggest that STYX is a pseudophosphatase that uses the 'competitor' and 'anchor' mode of action to exert its biologic roles. [review] PMID: 28408485
    3. results identify STYX as an important regulator of ERK1/2 signaling critical for cell migration PMID: 23847209
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 数据库链接：

    HGNC: 11447

    OMIM: 615814

    KEGG: hsa:6815

    STRING: 9606.ENSP00000346599

    UniGene: Hs.364980