STX8 Antibody
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货号:CSB-PA925784
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规格:¥1100
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图片:
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA925784(STX8 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
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The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA925784(STX8 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
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Gel: 12%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA925784(STX8 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 3 seconds
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其他:
产品详情
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Uniprot No.:Q9UNK0
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基因名:STX8
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别名:CARB antibody; STX 8 antibody; Stx8 antibody; STX8_HUMAN antibody; Syntaxin-8 antibody; Syntaxin8 antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Fusion protein of Human STX8
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,WB,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:30-1:150 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
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基因功能参考文献:
- Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules to functional lytic granules through the endosomal pathway in human cytotoxic t-lymphocytes. PMID: 27094127
- Increased STX8 expression in visceral adipose tissue appears to be associated with the presence of type 2 diabetes in obese patients through a mechanism that may involve GLUT4. PMID: 25523146
- Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability PMID: 25404741
- Syntaxin-8 regulates the endocytosis of TASK-1. PMID: 24743596
- These results suggest that STX8 mediates the recycling of CLDN16 and constitutes an important component of the CLDN16 trafficking machinery in the kidney. PMID: 24659781
- There are increases in CARB localized to intraneuronal neurofibrillary tangles and granulovacuolar degeneration in susceptible hippocampal and cortical neurons in Alzheimer's disease. PMID: 14991845
- syntaxin 8 contributes to the regulation of CFTR trafficking and chloride channel activity by the SNARE machinery PMID: 15039462
- Has two functionally distinct di-leucine-based motifs that act independently in its endocytic and exocytic processes. PMID: 17965969
- Palmitoylation does not affect the rate of protein turnover of syntaxins 7 and 8 nor does it influence the steady-state localization of syntaxin 8 in late endosomes. PMID: 18980942
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亚细胞定位:Membrane; Single-pass type IV membrane protein.
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蛋白家族:Syntaxin family
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组织特异性:Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.
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数据库链接:
HGNC: 11443
OMIM: 604203
KEGG: hsa:9482
STRING: 9606.ENSP00000305255
UniGene: Hs.431109
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