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  4. Recombinant Human Syntaxin-8 (STX8), partial

Recombinant Human Syntaxin-8 (STX8), partial

  • 中文名称：
    人STX8重组蛋白
  • 货号：
    CSB-YP892159HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人STX8重组蛋白
  • 货号：
    CSB-EP892159HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人STX8重组蛋白
  • 货号：
    CSB-EP892159HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人STX8重组蛋白
  • 货号：
    CSB-BP892159HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人STX8重组蛋白
  • 货号：
    CSB-MP892159HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    STX8
  • Uniprot No.：
  • 别名：
    CARB; STX 8; Stx8; STX8_HUMAN; Syntaxin-8; Syntaxin8
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
  • 基因功能参考文献：
    1. Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules to functional lytic granules through the endosomal pathway in human cytotoxic t-lymphocytes. PMID: 27094127
    2. Increased STX8 expression in visceral adipose tissue appears to be associated with the presence of type 2 diabetes in obese patients through a mechanism that may involve GLUT4. PMID: 25523146
    3. Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability PMID: 25404741
    4. Syntaxin-8 regulates the endocytosis of TASK-1. PMID: 24743596
    5. These results suggest that STX8 mediates the recycling of CLDN16 and constitutes an important component of the CLDN16 trafficking machinery in the kidney. PMID: 24659781
    6. There are increases in CARB localized to intraneuronal neurofibrillary tangles and granulovacuolar degeneration in susceptible hippocampal and cortical neurons in Alzheimer's disease. PMID: 14991845
    7. syntaxin 8 contributes to the regulation of CFTR trafficking and chloride channel activity by the SNARE machinery PMID: 15039462
    8. Has two functionally distinct di-leucine-based motifs that act independently in its endocytic and exocytic processes. PMID: 17965969
    9. Palmitoylation does not affect the rate of protein turnover of syntaxins 7 and 8 nor does it influence the steady-state localization of syntaxin 8 in late endosomes. PMID: 18980942

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  • 亚细胞定位：
    Membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    Syntaxin family
  • 组织特异性：
    Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.
  • 数据库链接：

    HGNC: 11443

    OMIM: 604203

    KEGG: hsa:9482

    STRING: 9606.ENSP00000305255

    UniGene: Hs.431109