Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. STC2 Antibody

STC2 Antibody

  • 货号：
    CSB-PA212583
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA212583(STC2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA212583(STC2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O76061
  • 基因名：
  • 别名：
    Stanniocalcin 2 antibody; Stanniocalcin related protein antibody; Stanniocalcin-2 antibody; Stanniocalcin-related protein antibody; Stanniocalcin2 antibody; STC 2 antibody; STC related protein antibody; STC-2 antibody; STC-related protein antibody; STC2 antibody; STC2_HUMAN antibody; STCRP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human STC2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
  • 基因功能参考文献：
    1. MiR-184 was confirmed to directly target STC2 in glioblastoma cells PMID: 28887636
    2. Results show that STC2 promotes head and neck squamous cell carcinoma cell proliferation, tumor growth, and metastasis through the PI3K/AKT/Snail pathway. PMID: 27863406
    3. STC2 promotes colorectal cancer tumorigenesis and epithelial-mesenchymal transition (EMT) progression through activating ERK/MEK and PI3K/AKT signaling pathways. PMID: 27662663
    4. Our results demonstrated the contrasting effects of STC1 and STC2-derived peptides on human macrophage foam cell formation associated with ACAT1 expression and on HASMC migration. PMID: 27346255
    5. Mus81 knockdown suppresses proliferation and survival of HCC cells likely by downregulating STC2 expression, implicating Mus81 as a therapeutic target for HCC. PMID: 27939696
    6. These findings indicated that STC2 may promote osteoblast differentiation and mineralization by regulating ERK activation PMID: 27878259
    7. STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis PMID: 26983002
    8. Data suggest that stanniocalcin 1 and 2 (STC1, STC2) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) during folliculogenesis. PMID: 26874357
    9. Up-regulation of CDK2 and CDK4 and down-regulation of cell cycle inhibitors p16 and p21 were observed after the delivery of STC2. Furthermore, STC2 transduction activated pAKT and pERK 1/2 signal pathways. PMID: 26424558
    10. This study utilized ER+ IBC to identify a metagene including ABAT and STC2 as predictive biomarkers for endocrine therapy resistance. PMID: 25771305
    11. STC2 may inhibit epithelial-mesenchymal transition at least partially through the PKC/Claudin-1-mediated signaling in human breast cancer cells. PMID: 25830567
    12. STC2 has a role in promoting cell proliferation and cisplatin resistance in cervical cancer PMID: 26361149
    13. The aim of this study was to evaluate the clinical value of measuring expression levels of STC2 in colorectal cancer (CRC) patients. PMID: 25234931
    14. Stanniocalcin 2 may contribute to tumor development and radioresistance in cervical cancer. PMID: 25674244
    15. These findings suggest that STC2 can be a potential lung cancer biomarker and plays a positive role in lung cancer metastasis and progression. PMID: 25463045
    16. Circulating STC1 and STC2 mRNA are potentially useful blood markers for LSCC PMID: 24743310
    17. High STC2 expression is associated with glioma. PMID: 24729417
    18. Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. PMID: 24503185
    19. STC2 overexpression correlates to poor prognosis for nasopharyngeal carcinomas. PMID: 24606961
    20. stanniocalcin 2 (STC2) was the most highly upregulated gene in anti-VEGF antibody-treated tumors PMID: 24375080
    21. Our results indicate that STC2 could be a useful molecular blood marker for predicting tumor progression by monitoring CTCs in patients with gastric cancer. PMID: 24100594
    22. Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways. PMID: 23664860
    23. High STC2 expression levels are associated with disease recurrence in patients with gastric cancer. PMID: 23548070
    24. High STC2 expression is associated with lymph node metastasis in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder. PMID: 23906305
    25. STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration. PMID: 23187001
    26. These findings point to three novel functions of STC2, and suggest that STC2 interacts with HO1 to form a eukaryotic 'stressosome' involved in the degradation of heme. PMID: 22503972
    27. High STC2 is associated with lymph node metastases in squamous cell esophageal carcinoma. PMID: 20734150
    28. Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth. PMID: 20174869
    29. High expression level of Stanniocalcin 2 is associated with gastric cancer. PMID: 20422456
    30. STC2 is a positive regulator in tumor progression at hypoxia. PMID: 20619259
    31. STC2 is a HIF-1 target gene and is involved in the regulation of cell proliferation. PMID: 19786016
    32. STC-2 can act as a potent growth inhibitor and reduce intramembranous and endochondral bone development and skeletal muscle growth, implying that these tissues are specific physiological targets of stanniocalcins PMID: 15367391
    33. Recombinant human and fish STC2 proteins were generated and found to be N-glycosylated homodimers. STC2 is a functional homodimeric glycoprotein, and thecal cell-derived STC2 could play a paracrine role during follicular development. PMID: 15486227
    34. NTN4, TRA1, and STC2 have roles in progression of breast cancer PMID: 17545519
    35. The induction of GDF15 and STC2 is likely specific to MK-4, vitamin K2 analog. PMID: 17909264
    36. elevated expression of STC-1 or STC-2 act as survival factors also for breast cancer cells and thereby contribute to tumor dormancy. PMID: 18355956
    37. STC2 was aberrantly hypermethylated in human cancer cells. PMID: 18394600
    38. Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitro. PMID: 18492817
    39. stanniocalcin 2 overexpression in a prostate cancer cell line promoted prostate cancer cell growth, indicating its oncogenic property PMID: 19298603
    40. Increased STC2 gene expression is associated with colorectal cancer. PMID: 19415750
    41. Stanniocalcin 2 promotes invasion and is associated with metastatic stages in neuroblastoma. PMID: 19582875

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Stanniocalcin family
  • 组织特异性：
    Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 11374

    OMIM: 603665

    KEGG: hsa:8614

    STRING: 9606.ENSP00000265087

    UniGene: Hs.233160