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  4. Recombinant Human Stanniocalcin-2 (STC2)

Recombinant Human Stanniocalcin-2 (STC2)

  • 货号：
    CSB-YP022822HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022822HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022822HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022822HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022822HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Stanniocalcin 2; Stanniocalcin related protein; Stanniocalcin-2; Stanniocalcin-related protein; Stanniocalcin2; STC 2; STC related protein; STC-2; STC-related protein; STC2; STC2_HUMAN; STCRP
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-302
  • 氨基酸序列
    TDATNP PEGPQDRSSQ QKGRLSLQNT AEIQHCLVNA GDVGCGVFEC FENNSCEIRG LHGICMTFLH NAGKFDAQGK SFIKDALKCK AHALRHRFGC ISRKCPAIRE MVSQLQRECY LKHDLCAAAQ ENTRVIVEMI HFKDLLLHEP YVDLVNLLLT CGEEVKEAIT HSVQVQCEQN WGSLCSILSF CTSAIQKPPT APPERQPQVD RTKLSRAHHG EAGHHLPEPS SRETGRGAKG ERGSKSHPNA HARGRVGGLG AQGPSGSSEW EDEQSEYSDI RR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
  • 基因功能参考文献：
    1. MiR-184 was confirmed to directly target STC2 in glioblastoma cells PMID: 28887636
    2. Results show that STC2 promotes head and neck squamous cell carcinoma cell proliferation, tumor growth, and metastasis through the PI3K/AKT/Snail pathway. PMID: 27863406
    3. STC2 promotes colorectal cancer tumorigenesis and epithelial-mesenchymal transition (EMT) progression through activating ERK/MEK and PI3K/AKT signaling pathways. PMID: 27662663
    4. Our results demonstrated the contrasting effects of STC1 and STC2-derived peptides on human macrophage foam cell formation associated with ACAT1 expression and on HASMC migration. PMID: 27346255
    5. Mus81 knockdown suppresses proliferation and survival of HCC cells likely by downregulating STC2 expression, implicating Mus81 as a therapeutic target for HCC. PMID: 27939696
    6. These findings indicated that STC2 may promote osteoblast differentiation and mineralization by regulating ERK activation PMID: 27878259
    7. STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis PMID: 26983002
    8. Data suggest that stanniocalcin 1 and 2 (STC1, STC2) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) during folliculogenesis. PMID: 26874357
    9. Up-regulation of CDK2 and CDK4 and down-regulation of cell cycle inhibitors p16 and p21 were observed after the delivery of STC2. Furthermore, STC2 transduction activated pAKT and pERK 1/2 signal pathways. PMID: 26424558
    10. This study utilized ER+ IBC to identify a metagene including ABAT and STC2 as predictive biomarkers for endocrine therapy resistance. PMID: 25771305
    11. STC2 may inhibit epithelial-mesenchymal transition at least partially through the PKC/Claudin-1-mediated signaling in human breast cancer cells. PMID: 25830567
    12. STC2 has a role in promoting cell proliferation and cisplatin resistance in cervical cancer PMID: 26361149
    13. The aim of this study was to evaluate the clinical value of measuring expression levels of STC2 in colorectal cancer (CRC) patients. PMID: 25234931
    14. Stanniocalcin 2 may contribute to tumor development and radioresistance in cervical cancer. PMID: 25674244
    15. These findings suggest that STC2 can be a potential lung cancer biomarker and plays a positive role in lung cancer metastasis and progression. PMID: 25463045
    16. Circulating STC1 and STC2 mRNA are potentially useful blood markers for LSCC PMID: 24743310
    17. High STC2 expression is associated with glioma. PMID: 24729417
    18. Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. PMID: 24503185
    19. STC2 overexpression correlates to poor prognosis for nasopharyngeal carcinomas. PMID: 24606961
    20. stanniocalcin 2 (STC2) was the most highly upregulated gene in anti-VEGF antibody-treated tumors PMID: 24375080
    21. Our results indicate that STC2 could be a useful molecular blood marker for predicting tumor progression by monitoring CTCs in patients with gastric cancer. PMID: 24100594
    22. Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways. PMID: 23664860
    23. High STC2 expression levels are associated with disease recurrence in patients with gastric cancer. PMID: 23548070
    24. High STC2 expression is associated with lymph node metastasis in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder. PMID: 23906305
    25. STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration. PMID: 23187001
    26. These findings point to three novel functions of STC2, and suggest that STC2 interacts with HO1 to form a eukaryotic 'stressosome' involved in the degradation of heme. PMID: 22503972
    27. High STC2 is associated with lymph node metastases in squamous cell esophageal carcinoma. PMID: 20734150
    28. Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth. PMID: 20174869
    29. High expression level of Stanniocalcin 2 is associated with gastric cancer. PMID: 20422456
    30. STC2 is a positive regulator in tumor progression at hypoxia. PMID: 20619259
    31. STC2 is a HIF-1 target gene and is involved in the regulation of cell proliferation. PMID: 19786016
    32. STC-2 can act as a potent growth inhibitor and reduce intramembranous and endochondral bone development and skeletal muscle growth, implying that these tissues are specific physiological targets of stanniocalcins PMID: 15367391
    33. Recombinant human and fish STC2 proteins were generated and found to be N-glycosylated homodimers. STC2 is a functional homodimeric glycoprotein, and thecal cell-derived STC2 could play a paracrine role during follicular development. PMID: 15486227
    34. NTN4, TRA1, and STC2 have roles in progression of breast cancer PMID: 17545519
    35. The induction of GDF15 and STC2 is likely specific to MK-4, vitamin K2 analog. PMID: 17909264
    36. elevated expression of STC-1 or STC-2 act as survival factors also for breast cancer cells and thereby contribute to tumor dormancy. PMID: 18355956
    37. STC2 was aberrantly hypermethylated in human cancer cells. PMID: 18394600
    38. Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitro. PMID: 18492817
    39. stanniocalcin 2 overexpression in a prostate cancer cell line promoted prostate cancer cell growth, indicating its oncogenic property PMID: 19298603
    40. Increased STC2 gene expression is associated with colorectal cancer. PMID: 19415750
    41. Stanniocalcin 2 promotes invasion and is associated with metastatic stages in neuroblastoma. PMID: 19582875

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Stanniocalcin family
  • 组织特异性：
    Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 11374

    OMIM: 603665

    KEGG: hsa:8614

    STRING: 9606.ENSP00000265087

    UniGene: Hs.233160