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SNAP23 Antibody

  • 货号：
    CSB-PA021871LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA021871LA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA021871LA01HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated ABC system.
    • Immunofluorescence staining of Hela cells with CSB-PA021871LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SNAP23 Polyclonal antibody
  • Uniprot No.：
    O00161
  • 基因名：
    SNAP23
  • 别名：
    HsT17016 antibody; LS-B8340 antibody; SNAP 23 antibody; SNAP-23 antibody; SNAP23 antibody; SNAP23A antibody; SNAP23B antibody; SNP23_HUMAN antibody; Synaptosomal associated protein 23 antibody; Synaptosomal associated protein 23kDa antibody; Synaptosomal associated protein antibody; Synaptosomal-associated protein 23 antibody; Vesicle membrane fusion protein SNAP 23 antibody; Vesicle membrane fusion protein SNAP23 antibody; Vesicle-membrane fusion protein SNAP-23 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Synaptosomal-associated protein 23 protein (90-196AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SNAP23 Antibody (CSB-PA021871LA01HU)，的标记方式是Non-conjugated。对于SNAP23 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021871LB01HU SNAP23 Antibody, HRP conjugated ELISA
    FITC CSB-PA021871LC01HU SNAP23 Antibody, FITC conjugated
    Biotin CSB-PA021871LD01HU SNAP23 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
  • 基因功能参考文献：
    1. PKM2 promotes tumor cell exosome release via phosphorylating protein SNAP23. PMID: 28067230
    2. SNAP23 suppressed progression of cervical cancer and induced cell cycle G2/M arrest via upregulating p21(cip1) and downregulating CyclinB1 PMID: 29908998
    3. Knockdown of VAMP3 and SNAP23 reduces endothelial secretion of miR-126-3p and miR-200a-3p, as well as the proliferation, migration, and suppression of contractile markers in smooth muscle cells caused by vascular endothelial cell-coculture. PMID: 28716920
    4. Study showed that SNAP23 was recruited to the close sites of lipid droplet (LD) in HCV-infected cells, implying that SNAP23 was required for HCV-induced LD enlargement and, HCV production. PMID: 27550144
    5. A novel regulatory mechanism for SNAP23-dependent mast cell activation of T. vaginalis-secreted LTB4 involving surface trafficking of BLT1. PMID: 27795355
    6. Study identified SNAP23 as a novel oncogene in Ovarian Cancer (OC). It is over-expressed in OC and could promote the proliferation, migration and invasion of OC in vitro. PMID: 27855700
    7. Localization of SNAP23 was found in plasma membrane, lipid droplets and mitochondria of skeletal muscle. PMID: 26733245
    8. these data suggest that SNAP23 is a key component of the endothelial SNARE machinery that mediates endothelial exocytosis. PMID: 26266817
    9. Increased level of SNAP23-Syntaxin4-VAMP7 interaction correlates with decreased Syntaxin4 phosphorylation and trafficking of MT1-MMP to invadopodia during cellular invasion. PMID: 24807903
    10. The association of Src, EGFR and beta1 integrin is dependent upon membrane traffic that is mediated by syntaxin13 (officially known as STX12) and SNAP23. PMID: 24496451
    11. Data suggest SNAP23 and VAMP3 (vesicle-associated membrane protein 3) participate in interleukin-1beta-, interleukin-1 receptor-, calcium signaling-dependent secretion/exocytosis of interleukin-6 and tumor necrosis factor alpha from synoviocytes. PMID: 24373201
    12. Results suggest that phagosomal SNAP-23 is one of the key players regulating the phagosomal environment in macrophages. PMID: 23087210
    13. STX-3 and SNAP-23 are crucial for the release of all chemokines in mature human mast cells PMID: 21981832
    14. Data show that knockdown of SNAP-23 inhibited the production of virus. PMID: 21768361
    15. Introduction of the SNARE domain of SNAP-23 into neutrophils as an HIV transactivator of transcription (TAT) fusion protein significantly inhibits exocytosis of neutrophil granule subsets without altering signal transduction pathway activation. PMID: 21642540
    16. SNAP23 and SNAP25 palmitoylation is regulated by DHHC palmitoyl transferases PMID: 20519516
    17. the importance of SNAP23 in the trafficking of matrix metalloproteinases during degradation of extracellular matrix substrates and subsequent cellular invasion PMID: 19910495
    18. SNAP-23 and syntaxin-4 are expressed in human eosinophils and are likely candidates for association with VAMP-2 during docking, which is followed by exocytosis. PMID: 11842301
    19. cleaved by calpain in activated platelets PMID: 12121992
    20. CFTR-mediated chloride currents are inhibited by introducing excess SNAP-23 into HT29-Cl.19A epithelial cells. PMID: 12209004
    21. A synaptosome-associated protein of 23 kDa(SNAP23), the ubiqitously expressed homologue of SNAP25, has been shown to interact directly with ubiquitous kinesin heavy chain (uKHC). PMID: 12475239
    22. Palmitoylated peptides from the cysteine-rich domain of this protein cause membrane fusion depending on peptide length, position of cysteines, and extent of palmitoylation. PMID: 12551899
    23. an examination of the homotetrameric structure of the N-terminal domain of this protein PMID: 12556468
    24. studies show that synaptosomal-associated protein-23 is phosphorylated in platelets during cell activation through a protein kinase C-related mechanism at two or more sites PMID: 12930825
    25. Because SNAP-23 plays a central role in SNAREs complex formation, it was chosen to examine possible functional implications of the SNARE system in plasma cell Ig secretion. PMID: 16272324
    26. expression of SNAP-23 and syntaxin-2 on the extracellular surface of the platelet plasma membrane. PMID: 17485553
    27. SNAP-23 is not essential for constitutive exocytosis of secreted alkaline phosphatase PMID: 17825825
    28. The expression of the SNARE protein SNAP-25 and its cellular homologue SNAP-23, as well as syntaxin1 and VAMP (vesicle-associated membrane protein) in samples of normal parathyroid tissue, chief cell adenoma, and parathyroid carcinoma, was examined. PMID: 18457912
    29. Overexpression of a dominant negative SNAP-23 mutant suppressed expression of P-selectin, CD40L, CD41, CD61, release from dense granules and platelet aggregation PMID: 18665925

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Mainly localized to the plasma membrane.
  • 蛋白家族：
    SNAP-25 family
  • 组织特异性：
    Ubiquitous. Highest levels where found in placenta.
  • 数据库链接：

    HGNC: 11131

    OMIM: 602534

    KEGG: hsa:8773

    STRING: 9606.ENSP00000249647

    UniGene: Hs.511149