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SMPDL3A Antibody

  • 货号：
    CSB-PA842119LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA842119LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA842119LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SMPDL3A Polyclonal antibody
  • Uniprot No.：
    Q92484
  • 基因名：
    SMPDL3A
  • 别名：
    SMPDL3A antibody; ASML3AAcid sphingomyelinase-like phosphodiesterase 3a antibody; ASM-like phosphodiesterase 3a antibody; EC 3.1.4.- antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a protein (51-350AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SMPDL3A Antibody (CSB-PA842119LA01HU)，的标记方式是Non-conjugated。对于SMPDL3A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA842119LB01HU SMPDL3A Antibody, HRP conjugated ELISA
    FITC CSB-PA842119LC01HU SMPDL3A Antibody, FITC conjugated
    Biotin CSB-PA842119LD01HU SMPDL3A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity.
  • 基因功能参考文献：
    1. Activation of pregnane X receptor induces SMPDL3A expression in primary hepatocytes. PMID: 28414139
    2. Site-specific N-glycosylation is essential for the intracellular stability, secretion and activity of human SMPDL3A. PMID: 28104755
    3. Solved the structure of SMPDL3a revealing a calcineurin-like fold. A dimetal site, glycosylation pattern and a disulfide bond network are likely to be conserved also in aSMase. We show that the binuclear site of SMPDL3a is occupied by two Zn(2+) ions. PMID: 26783088
    4. Data indicate that sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a nucleotide phosphodiesterase secreted from cholesterol-loaded macrophages. PMID: 25288789
    5. the induction of SMPDL3A is liver X receptor-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. PMID: 22810003
    6. ASML3a is involved in the process of bladder tumorigenesis PMID: 12442002

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Acid sphingomyelinase family
  • 组织特异性：
    Detected in blood serum. Detected in macrophages (at protein level).
  • 数据库链接：

    HGNC: 17389

    OMIM: 610728

    KEGG: hsa:10924

    STRING: 9606.ENSP00000357425

    UniGene: Hs.486357