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SMARCA5 Antibody

  • 货号：
    CSB-PA021802GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O60264
  • 基因名：
  • 别名：
    4933427E24Rik antibody; D030040M08Rik antibody; D330027N15Rik antibody; EC 3.6.1.- antibody; hISWI antibody; hSNF2H antibody; ISWI antibody; MommeD4 antibody; SMARCA5 antibody; SMCA5_HUMAN antibody; Snf2h antibody; Sucrose nonfermenting like 5 antibody; Sucrose nonfermenting protein 2 homolog antibody; Sucrose nonfermenting, yeast, homolog of antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 antibody; WCRF135 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SMARCA5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails. Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template. Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes. The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template. Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase. Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription. Within the B-WICH complex has a role in RNA polymerase III transcription. Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
  • 基因功能参考文献：
    1. our data show circSMARCA5 as a promising druggable tumor suppressor in GBM and suggest that it may exert its function by tethering the RBP SRSF1. PMID: 29415469
    2. miR-151-5p, targeting chromatin remodeler SMARCA5, may act as a useful biomarker for BRCA-related and sporadic breast cancers. PMID: 27385001
    3. BAZ1A and BAZ1B promote recovery after DNA damage in part by recruiting SMARCA5 to damaged chromatin. PMID: 29021563
    4. Overexpression of hSNF2H is associated with glioma. PMID: 26666816
    5. The action of SNF2H at CTCF sites is functionally important as depletion of CTCF or SNF2H affects transcription of a common group of genes. PMID: 27019336
    6. Knockdown of SMARCA5 expression in MDA-MB-231 and MDA-MB-435s cell lines. PMID: 25377162
    7. Data show the mechanism of nucleosome sliding by the chromatin remodeling motor SNF2h protein. PMID: 25684208
    8. CHD3.1 and ACF1-SNF2H display counteractive activities but similar histone affinities. PMID: 25533843
    9. Data show that CCCTC-binding factor (CTCF) together with ISWI ATPase SMARCA5 and members of the Cohesin complex associate with the SPI1 protein is disrupted in acute myeloid leukemia (AML) blasts. PMID: 24498324
    10. SMARCA5 targeting to UV-C damage depends on transcription and histone modifications and requires functional SWI2/SNF2-ATPase and SLIDE domains. PMID: 24990377
    11. this study finds that the H4 tail promotes ATP-binding pocket closure in SNF2h. PMID: 24607692
    12. study unveils a functional link between DNA damage-induced poly(ADP-ribosyl)ation, SMARCA5-mediated chromatin remodeling and RNF168-dependent signaling and repair of DSBs. PMID: 23264744
    13. Data indicate that the heterochromatic H2A.X is preferentially phosphorylated presumably by the accumulating WSTF-ISWI chromatin remodeling (WICH) complex, and suggests that Tyr142p might have a specific role in heterochromatin. PMID: 23319141
    14. Introduction of the miR-99 family of miRNAs into cells reduced the rate and overall efficiency of repair by both homologous recombination and non-homologous end joining. PMID: 22525276
    15. Functional interaction is characterized between C/EBPbeta and SNF2H/ACF1, involving mainly suppression of C/EBPbeta transactivation activity in the presence of SNF2H and ACF1. PMID: 22242598
    16. [review] Biochemical analysis using a mutant Vpr HIV-1 gene suggests that Vpr binds chromatin-remodeling factor SNF2h via HFRIG (i.e., amino acids 71-75). PMID: 21519849
    17. These results demonstrate a novel role for ISWI (SNF2h) as a survival factor during the cellular response to hypoxia PMID: 21900490
    18. ISWI proteins Snf2H, Snf2L as well as Acf1 accumulate at UV-induced DNA damage sites within tens of seconds and reach a plateau after a few minutes. PMID: 21738833
    19. Cdt1- and SNF2H-mediated promotion of MCM loading may be biologically relevant for the regulation of DNA replication. PMID: 21937426
    20. SNF2H is required for efficient HSV-1 replication and promotes virus immediate-early gene expression. PMID: 21249171
    21. This is the first description of a fusion between EWSR1 and a chromatin-reorganizing gene(SMARCA5) in Ewing sarcoma/PNET. PMID: 21113140
    22. SMARCA5 has a potential role in proliferation and malignancy in gastric carcinogenesis. PMID: 21261476
    23. The ATP-dependent chromatin-remodeling factor, SNF2H, accumulate rapidly at DSBs and is required for DSB repair in human cells. PMID: 21172662
    24. ISWI remodelers operate via a "continuous sampling" mechanism. PMID: 20974961
    25. Data conclude that H2A.Z incorporation increases nucleosome remodeling activity of the largest class of mammalian remodelers (ISWI) and that it correlates with increased association of other remodelers to chromatin. PMID: 19940112
    26. Human RSF is composed of two subunits: ATPase hSNF2H and p325 (Rsf-1). PMID: 12972596
    27. WSTF-ISWI complex has a role in the maintenance of chromatin structures during DNA replication. PMID: 15543136
    28. Nuclear myosin 1 (NM1)-Williams syndrome transcription factor (WSTF)-SMARCA5/SNF2h complex binds RNA polymerase I and ribosomal DNA rDNA). PMID: 16514417
    29. WSTF-SNF2h-NM1 forms a platform in transcription while providing chromatin remodeling PMID: 16603771
    30. ACF1 alters the remodeling strategy of SNF2h PMID: 16877760
    31. findings suggest that interaction between Rsf-1 and hSNF2H may define a survival signal in those tumors overexpressing Rsf-1 PMID: 18519663
    32. The ability to sense adjacent DNA is a general property of the binding partners of SNF2h and that each partner provides distinct regulation that contributes to distinct cellular function. PMID: 18553938

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    SNF2/RAD54 helicase family, ISWI subfamily
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 11101

    OMIM: 603375

    KEGG: hsa:8467

    STRING: 9606.ENSP00000283131

    UniGene: Hs.558422