SMARCA5
SMARCA5,即SWI/SNF相关矩阵相关作用蛋白A5,也称为SNF2L、BAF170或hBRM。它是一种由SMARCA5基因编码的蛋白质,属于SWI/SNF染色质重塑复合体的成员。SMARCA5在细胞核中发挥作用,其作用机制涉及利用ATP水解的能量,改变染色质结构,从而调节基因的转录。它通过滑动或重构核小体位置,增加或减少转录因子对DNA的访问性。SMARCA5参与的信号通路包括多种细胞周期调控、细胞增殖、分化和DNA损伤响应等过程。在生物学意义上,SMARCA5对维持基因组稳定性、调控细胞命运和参与发育过程至关重要。它的异常表达或功能丧失与多种肿瘤的发生发展有关,尤其在某些类型的癌症中,SMARCA5的突变与肿瘤的侵袭性和预后密切相关,使其成为癌症研究和治疗的潜在靶点。
热销产品
SMARCA5 Antibody (CSB-PA150330)
验证数据
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Hepg2 cells, MCF7 cells, Jurkat cells, hela cells, A431 cells, K562 cells, lncap cells, Primary antibody: CSB-PA150330(SMARCA5 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
SMARCA5 Antibodies
SMARCA5 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA021802GA01HU | SMARCA5 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA150330 | SMARCA5 Antibody | Human,Mouse | ELISA,WB |
SMARCA5 Proteins
SMARCA5 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP021802HU CSB-EP021802HU CSB-BP021802HU CSB-MP021802HU CSB-EP021802HU-B |
Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |