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SLCO2A1 Antibody

  • 货号：
    CSB-PA856440LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, 293T whole cell lysate, HepG2 whole cell lysate, U87 whole cell lysate, K562 whole cell lysate, Rat brain tissue, Mouse heart tissue, Mouse liver tissue
      All lanes: SLCO2A1 antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 71 kDa
      Observed band size: 71 kDa
    • IHC image of CSB-PA856440LA01HU diluted at 1:500 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA856440LA01HU diluted at 1:500 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA856440LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品描述：

    The SLCO2A1 polyclonal antibody from CUSABIO is a high-quality antibody that has been validated for use in ELISA, WB, IHC, and IF. The immunogen is the recombinant human SLCO2A1 protein (416-518aa). This SLCO2A1 antibody is purified using protein G and has a purity of over 95%. It has been shown to detect SLCO2A1 in human, mouse, and rat samples.

    The SLCO2A1 protein, also known as prostaglandin transporter (PGT), mainly transports prostaglandins across cell membranes, particularly in the kidney and the gastrointestinal tract. Mutations in the SLCO2A1 gene can lead to a rare disorder known as primary hypertrophic osteoarthropathy (PHO).

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLCO2A1 Polyclonal antibody
  • Uniprot No.：
    Q92959
  • 基因名：
    SLCO2A1
  • 别名：
    SLCO2A1 antibody; OATP2A1 antibody; SLC21A2 antibody; Solute carrier organic anion transporter family member 2A1 antibody; Prostaglandin transporter antibody; PGT antibody; Solute carrier family 21 member 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Solute carrier organic anion transporter family member 2A1 protein (416-518AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLCO2A1 Antibody (CSB-PA856440LA01HU)，的标记方式是Non-conjugated。对于SLCO2A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA856440LB01HU SLCO2A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA856440LC01HU SLCO2A1 Antibody, FITC conjugated
    Biotin CSB-PA856440LD01HU SLCO2A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transports PGD2, as well as PGE1, PGE2 and PGF2A. Mediates the clearance of prostaglandins from the circulation through uptake across cell membrane which allows cytoplasmic oxidation and prostaglandin signal termination. May mediate the release of newly synthesized prostaglandins from cells and the transepithelial transport of prostaglandins (Probable).
  • 基因功能参考文献：
    1. The findings reported here support causality of this SLCO2A1 mutation for autosomal recessive ICNC in this consanguineous Pakistani kindred. PMID: 27681482
    2. In Japanese patients with chronic nonspecific multiple ulcers of the small intestine, 2 of the 4 patients had mutation in the SLCO2A1 gene, became resistant to medical therapy, and underwent strictureplasty or ileal resection after long-term follow-up. PMID: 27467110
    3. in individuals carrying the SLCO2A1 A396T variant, the combination of thiazide-specific effects on free water generation and the increase in collecting duct water permeability from reduced SLCO2A1 activity combine to produce thiazide-induced hyponatremia PMID: 28783044
    4. A novel missense mutation c.101T > C in the SLCO2A1 gene causes pachydermoperiostosis of the complete type. PMID: 28602931
    5. Mutation analysis revealed a novel heterozygous mutation in the solute carrier organic anion transporter family member 2A1 gene at nucleotide 302 causing a substitution of the amino acid isoleucine to serine at codon 101 (p.IIe101Ser) in affected individuals. PMID: 27134495
    6. We herein report patients with pachydermoperiostosis (PDP)due to SLCO2A1 mutation in a Korean family. Similar to other East Asian populations, the SLCO2A1 gene may be a possible mutation spot of PDP in the Korean population. PMID: 25810087
    7. Data show that prostaglandin E3 (PGE3) uptake by prostaglandin transporter OATP2A1-expressing HEK293 cells (HEK/2A1) was the highest and followed by SLCO2B1 (HEK/1B1). PMID: 26692285
    8. In this article we describe a novel mutation in the SLCO2A1 causing Pachydermoperiostosis in a Lebanese family PMID: 25059581
    9. overexpression of SLCO2A1 could induce and knockdown inhibit the invasion of lung cancer cells. expression levels of p-mTOR, p-AKT and p-S6 were up-regulated or down-regulated with the overexpression or knockdown of SLCO2A1. PMID: 26464663
    10. cytoplasmic OATP2A1 likely facilitates prostaglandin E2 loading into suitable intracellular compartment(s) for efficient exocytotic prostaglandin E2 release from colorectal cancer cells exposed to oxidative stress PMID: 26850138
    11. findings indicate that loss-of-function mutations in the SLCO2A1 gene encoding a prostaglandin transporter cause the hereditary enteropathy CNSU PMID: 26539716
    12. SLCO2A1 and NOS3 are involved with prostaglandin reuptake/metabolism and nitric oxide production, respectively, and are consistently decreased in "non-Caucasian" fetal ductus arteriosus PMID: 26265282
    13. Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer. PMID: 25433169
    14. OATP2A1 also diminished the PGE2-mediated expression of interleukin-8 mRNA (IL-8) and hypoxia-inducible-factor 1alpha (HIF1alpha) protein in AGS-OATP2A1 cells. PMID: 25433165
    15. SLCO2A1 has a role in familial digital clubbing, colon neoplasia, and NSAID resistance PMID: 24838973
    16. a novel nonsense mutation p.E141* of the SLCO2A1 gene is associated with pachydermoperiostosis PMID: 24929850
    17. Three novel mutations within the SLCO2A1 gene have been demonstrated to be associated with Chinese primary hypertrophic osteoarthropathy patients. PMID: 24153155
    18. Identified two novel mutations in SLCO2A1. PMID: 24185079
    19. genetic association study in population in China: Nine different SLCO2A1 mutations were identified in subjects with primary hypertrophic osteoarthropathy (PHO) in 7 previously undescribed families; different homozygous mutations of SLCO2A1 cause PHO. PMID: 23509104
    20. Report SLCO2A1 is a novel gene responsible for pachydermoperiostosis in Japanese patients. PMID: 22906430
    21. Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing. PMID: 22696055
    22. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. PMID: 22553128
    23. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. PMID: 22331663
    24. The findings confirmed that SLCO2A1 mutations inactivate prostaglandin E2 transport, and they indicated that mutations in SLCO2A1 are the pathogenic cause of primary hypertrophic osteoarthropathy. PMID: 22197487
    25. expression in fetal membranesfound primarily in the choriodecidua PMID: 20357271
    26. that PGT may play a role in transporting PGH(2) across cellular membranes. PMID: 20346915
    27. Human endometrial stromal cells treated with a combination of cAMP and medroxyprogesterone acetate to induce decidualization showed an increase in protein and mRNA levels. PMID: 16339169
    28. PGT level was significantly less in AD than in age-matched control brain homogenates. PMID: 18353443
    29. The existing model to explain increased PGE(2) in colorectal neoplasia should be modified to include the novel mechanism of coordinated up- and down-regulation of genes involved in PGE(2) transport. PMID: 19138942

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  • 相关疾病：
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Organo anion transporter (TC 2.A.60) family
  • 组织特异性：
    Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.
  • 数据库链接：

    HGNC: 10955

    OMIM: 601460

    KEGG: hsa:6578

    STRING: 9606.ENSP00000311291

    UniGene: Hs.518270