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  4. Recombinant Human Solute carrier organic anion transporter family member 2A1 (SLCO2A1), partial

Recombinant Human Solute carrier organic anion transporter family member 2A1 (SLCO2A1), partial

  • 中文名称：
    人SLCO2A1重组蛋白
  • 货号：
    CSB-YP856440HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLCO2A1重组蛋白
  • 货号：
    CSB-EP856440HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLCO2A1重组蛋白
  • 货号：
    CSB-EP856440HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLCO2A1重组蛋白
  • 货号：
    CSB-BP856440HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLCO2A1重组蛋白
  • 货号：
    CSB-MP856440HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLCO2A1
  • Uniprot No.：
  • 别名：
    SLCO2A1; OATP2A1; SLC21A2; Solute carrier organic anion transporter family member 2A1; Prostaglandin transporter; PGT; Solute carrier family 21 member 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transports PGD2, as well as PGE1, PGE2 and PGF2A. Mediates the clearance of prostaglandins from the circulation through uptake across cell membrane which allows cytoplasmic oxidation and prostaglandin signal termination. May mediate the release of newly synthesized prostaglandins from cells and the transepithelial transport of prostaglandins (Probable).
  • 基因功能参考文献：
    1. The findings reported here support causality of this SLCO2A1 mutation for autosomal recessive ICNC in this consanguineous Pakistani kindred. PMID: 27681482
    2. In Japanese patients with chronic nonspecific multiple ulcers of the small intestine, 2 of the 4 patients had mutation in the SLCO2A1 gene, became resistant to medical therapy, and underwent strictureplasty or ileal resection after long-term follow-up. PMID: 27467110
    3. in individuals carrying the SLCO2A1 A396T variant, the combination of thiazide-specific effects on free water generation and the increase in collecting duct water permeability from reduced SLCO2A1 activity combine to produce thiazide-induced hyponatremia PMID: 28783044
    4. A novel missense mutation c.101T > C in the SLCO2A1 gene causes pachydermoperiostosis of the complete type. PMID: 28602931
    5. Mutation analysis revealed a novel heterozygous mutation in the solute carrier organic anion transporter family member 2A1 gene at nucleotide 302 causing a substitution of the amino acid isoleucine to serine at codon 101 (p.IIe101Ser) in affected individuals. PMID: 27134495
    6. We herein report patients with pachydermoperiostosis (PDP)due to SLCO2A1 mutation in a Korean family. Similar to other East Asian populations, the SLCO2A1 gene may be a possible mutation spot of PDP in the Korean population. PMID: 25810087
    7. Data show that prostaglandin E3 (PGE3) uptake by prostaglandin transporter OATP2A1-expressing HEK293 cells (HEK/2A1) was the highest and followed by SLCO2B1 (HEK/1B1). PMID: 26692285
    8. In this article we describe a novel mutation in the SLCO2A1 causing Pachydermoperiostosis in a Lebanese family PMID: 25059581
    9. overexpression of SLCO2A1 could induce and knockdown inhibit the invasion of lung cancer cells. expression levels of p-mTOR, p-AKT and p-S6 were up-regulated or down-regulated with the overexpression or knockdown of SLCO2A1. PMID: 26464663
    10. cytoplasmic OATP2A1 likely facilitates prostaglandin E2 loading into suitable intracellular compartment(s) for efficient exocytotic prostaglandin E2 release from colorectal cancer cells exposed to oxidative stress PMID: 26850138
    11. findings indicate that loss-of-function mutations in the SLCO2A1 gene encoding a prostaglandin transporter cause the hereditary enteropathy CNSU PMID: 26539716
    12. SLCO2A1 and NOS3 are involved with prostaglandin reuptake/metabolism and nitric oxide production, respectively, and are consistently decreased in "non-Caucasian" fetal ductus arteriosus PMID: 26265282
    13. Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer. PMID: 25433169
    14. OATP2A1 also diminished the PGE2-mediated expression of interleukin-8 mRNA (IL-8) and hypoxia-inducible-factor 1alpha (HIF1alpha) protein in AGS-OATP2A1 cells. PMID: 25433165
    15. SLCO2A1 has a role in familial digital clubbing, colon neoplasia, and NSAID resistance PMID: 24838973
    16. a novel nonsense mutation p.E141* of the SLCO2A1 gene is associated with pachydermoperiostosis PMID: 24929850
    17. Three novel mutations within the SLCO2A1 gene have been demonstrated to be associated with Chinese primary hypertrophic osteoarthropathy patients. PMID: 24153155
    18. Identified two novel mutations in SLCO2A1. PMID: 24185079
    19. genetic association study in population in China: Nine different SLCO2A1 mutations were identified in subjects with primary hypertrophic osteoarthropathy (PHO) in 7 previously undescribed families; different homozygous mutations of SLCO2A1 cause PHO. PMID: 23509104
    20. Report SLCO2A1 is a novel gene responsible for pachydermoperiostosis in Japanese patients. PMID: 22906430
    21. Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing. PMID: 22696055
    22. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. PMID: 22553128
    23. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. PMID: 22331663
    24. The findings confirmed that SLCO2A1 mutations inactivate prostaglandin E2 transport, and they indicated that mutations in SLCO2A1 are the pathogenic cause of primary hypertrophic osteoarthropathy. PMID: 22197487
    25. expression in fetal membranesfound primarily in the choriodecidua PMID: 20357271
    26. that PGT may play a role in transporting PGH(2) across cellular membranes. PMID: 20346915
    27. Human endometrial stromal cells treated with a combination of cAMP and medroxyprogesterone acetate to induce decidualization showed an increase in protein and mRNA levels. PMID: 16339169
    28. PGT level was significantly less in AD than in age-matched control brain homogenates. PMID: 18353443
    29. The existing model to explain increased PGE(2) in colorectal neoplasia should be modified to include the novel mechanism of coordinated up- and down-regulation of genes involved in PGE(2) transport. PMID: 19138942

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  • 相关疾病：
    Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Organo anion transporter (TC 2.A.60) family
  • 组织特异性：
    Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.
  • 数据库链接：

    HGNC: 10955

    OMIM: 601460

    KEGG: hsa:6578

    STRING: 9606.ENSP00000311291

    UniGene: Hs.518270