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SLC9A7 Antibody

  • 货号：
    CSB-PA070041
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q96T83
  • 基因名：
    SLC9A7
  • 别名：
    Na(+)/H(+) exchanger 7 antibody; NHE-7 antibody; NHE7 antibody; Nonselective sodium potassium/proton exchanger antibody; SL9A7_HUMAN antibody; SLC9A6 antibody; SLC9A7 antibody; Sodium/hydrogen exchanger 7 antibody; Solute carrier family 9 (sodium/hydrogen exchanger), member 7 antibody; Solute carrier family 9 member 7 antibody; Solute carrier family 9, isoform 7 antibody; Solute carrier family 9, member 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human NHE-7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to the regulation of Golgi apparatus volume and pH.
  • 基因功能参考文献：
    1. In a Saudi Arabian cohort of patients with cystinuria, two new variants in the SLC3A1 and SLC9A7 genes were discovered. All of the detected mutations were missense variants in three different exons, such as c.1711 T > A (p.Cys571Ser) (exon 10), c.1166C > T p.Thr389Met (exon 11) and c.1400 T > A p.Met467Lys (exon 8). PMID: 28166740
    2. NHE7 mediates an acidification of intracellular vesicles that is additive to that of V-ATPases and that accelerates endocytosis. PMID: 24767989
    3. these results suggest that NHE7 enhances tumor progression. PMID: 22076128
    4. This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane. PMID: 21171650
    5. The results suggest that two membrane proximal regions (residues 533-559 and 563-568) play an important role in targeting NHE7 to the TGN PMID: 20364249
    6. Secretory carrier membrane proteins participate in the shuttling of NHE7 between recycling vesicles and the TGN PMID: 15840657
    7. Among the NHE7-binding proteins identified, CD44, a cell surface glycoprotein receptor for hyaluronate and other ligands, showed regulated interaction with NHE7. PMID: 18654930

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 17123

    OMIM: 300368

    KEGG: hsa:84679

    STRING: 9606.ENSP00000330320

    UniGene: Hs.91389