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  4. Recombinant Human Sodium/hydrogen exchanger 7 (SLC9A7), partial

Recombinant Human Sodium/hydrogen exchanger 7 (SLC9A7), partial

  • 中文名称：
    人SLC9A7重组蛋白
  • 货号：
    CSB-YP850435HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC9A7重组蛋白
  • 货号：
    CSB-EP850435HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC9A7重组蛋白
  • 货号：
    CSB-EP850435HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC9A7重组蛋白
  • 货号：
    CSB-BP850435HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC9A7重组蛋白
  • 货号：
    CSB-MP850435HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC9A7
  • Uniprot No.：
  • 别名：
    Na(+)/H(+) exchanger 7; NHE-7; NHE7; Nonselective sodium potassium/proton exchanger; SL9A7_HUMAN; SLC9A6; SLC9A7; Sodium/hydrogen exchanger 7; Solute carrier family 9 (sodium/hydrogen exchanger), member 7; Solute carrier family 9 member 7; Solute carrier family 9, isoform 7; Solute carrier family 9, member 7
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to the regulation of Golgi apparatus volume and pH.
  • 基因功能参考文献：
    1. In a Saudi Arabian cohort of patients with cystinuria, two new variants in the SLC3A1 and SLC9A7 genes were discovered. All of the detected mutations were missense variants in three different exons, such as c.1711 T > A (p.Cys571Ser) (exon 10), c.1166C > T p.Thr389Met (exon 11) and c.1400 T > A p.Met467Lys (exon 8). PMID: 28166740
    2. NHE7 mediates an acidification of intracellular vesicles that is additive to that of V-ATPases and that accelerates endocytosis. PMID: 24767989
    3. these results suggest that NHE7 enhances tumor progression. PMID: 22076128
    4. This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane. PMID: 21171650
    5. The results suggest that two membrane proximal regions (residues 533-559 and 563-568) play an important role in targeting NHE7 to the TGN PMID: 20364249
    6. Secretory carrier membrane proteins participate in the shuttling of NHE7 between recycling vesicles and the TGN PMID: 15840657
    7. Among the NHE7-binding proteins identified, CD44, a cell surface glycoprotein receptor for hyaluronate and other ligands, showed regulated interaction with NHE7. PMID: 18654930

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 17123

    OMIM: 300368

    KEGG: hsa:84679

    STRING: 9606.ENSP00000330320

    UniGene: Hs.91389