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SLC6A6 Antibody

  • 货号：
    CSB-PA546856
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from COLO205 cells, using SC6A6 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SC6A6 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC6A6 Polyclonal antibody
  • Uniprot No.：
    P31641
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human SC6A6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
  • 基因功能参考文献：
    1. TauT gene expression is significantly upregulated in mononuclear leukocytes of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine. PMID: 26955642
    2. CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy PMID: 26206726
    3. This is the first study to present information on the transcriptional regulation of taurine transporter gene and the localization of the taurine transporter protein in chondrocytic cells. PMID: 25501278
    4. Neurotransmitter transporters including SLC6A6 and SLC6A13 mediate the uptake of 5-aminolevulinic acid (ALA) and can play roles in the enhancement of ALA-induced accumulation of protoporphyrin in cancerous cells. PMID: 24842606
    5. Immunocytochemistry and flow cytometry analyses revealed that these mAbs recognized the native form of the extracellular domain of SLC6A6 on the cell surface. PMID: 24866236
    6. Taurine transporter is a novel pathological marker for stressed motor neurons in amyotrophic lateral sclerosis. PMID: 23180277
    7. Taurine transporter deficiency results in aberrant trophoblast turnover and fetal growth restriction. PMID: 23519128
    8. Syncytiotrophoblast TauT activity is reduced in maternal obesity and pre-eclampsia compared to normal pregnancy. PMID: 23392873
    9. Knockdown of TauT impairs kidney development, possibly through regulation of cell cycle-related genes. PMID: 23392892
    10. TauT gene is overexpressed in peripheral blood mononuclear cells of type 2 diabetic patients. PMID: 21739148
    11. TNF-alpha-treated cells showed a higher mRNA level of the TAUT (taurine transporter) than did the control cells. PMID: 12062416
    12. TauT is involved with p53 in renal development and apoptosis. PMID: 12163498
    13. regulation by WT1 PMID: 12681485
    14. nitric oxide plays an important role in downregulating microvillous plasma membrane taurine transporter activity in intrauterine growth restriction PMID: 15166008
    15. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca(2+)/CaM kinase II inhibitor. PMID: 15225620
    16. TAUT activity in TNF-alpha-treated Caco-2 cells suggests that up-regulation was associated with an increase in the amount of TAUT. PMID: 15630186
    17. reporter assay revealed that TNF-alpha-induced TAUT transcriptional activity through the NF-kappaB consensus-like sequence in the human TAUT promoter region PMID: 15907840
    18. taurine cotransporter is regulated by oxidative stress and overexpression of aldose reductase and high glucose impair this response PMID: 16356117
    19. Greater system beta activity in fetal platelets compared with T lymphocytes is the result of relatively greater TAUT mRNA and protein expression. PMID: 16956961
    20. Report taurine transporter activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
    21. This study demonstrates the functional coexpression of TauT along with the PAT1 transporter (SLC36A1) at the apical membrane of the intestinal epithelium. PMID: 19074966
    22. critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway PMID: 19423693
    23. Glucose reduced taurine transporter (TauT) mRNA and protein in a dose-dependent manner. PMID: 19602579

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A6 subfamily
  • 组织特异性：
    Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver.
  • 数据库链接：

    HGNC: 11052

    OMIM: 186854

    KEGG: hsa:6533

    STRING: 9606.ENSP00000354107

    UniGene: Hs.529488