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SLC6A6 Antibody

  • 货号：
    CSB-PA021704LA01HU
  • 规格：
    ￥880
  • 图片：
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate, HL60 whole cell lysate,Mouse Brain tissue lysate,Mouse Liver tissue lysate
      All lanes: SLC6A6 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 70 kDa
      Observed band size: 70 kDa
    • Immunofluorescent analysis of MCF7 cells using CSB-PA021704LA01HU at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    SLC6A6 polyclonal antibody CSB-PA021704LA01HU was produced in the rabbit. The recombinant human sodium- and chloride-dependent taurine transporter protein (1-49aa) is used as the immunogen. The non-conjugated IgG got purified by the antigen affinity method and has high purity.

    This rabbit anti-human SLC6A6 polyclonal antibody only reacts with the SLC6A6 proteins of human origin and may be used to detect the endogenous levels of SLC6A6 protein. It has got quality tested in the ELISA, WB, and IF applications. The users can use this antibody to detect the levels, identify the presence and size, and trace the position of the SLC6A6 protein.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC6A6 Polyclonal antibody
  • Uniprot No.：
    P31641
  • 基因名：
  • 别名：
    MGC10619 antibody; MGC131729 antibody; OTTHUMP00000208177 antibody; OTTHUMP00000208180 antibody; SC6A6_HUMAN antibody; SLC6A6 antibody; Sodium- and chloride-dependent taurine transporter antibody; Solute carrier family 6 (neurotransmitter transporter, taurine), member 6 antibody; Solute carrier family 6 member 6 antibody; TAUT antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Sodium- and chloride-dependent taurine transporter protein (1-49AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC6A6 Antibody (CSB-PA021704LA01HU)，的标记方式是Non-conjugated。对于SLC6A6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021704LB01HU SLC6A6 Antibody, HRP conjugated ELISA
    FITC CSB-PA021704LC01HU SLC6A6 Antibody, FITC conjugated
    Biotin CSB-PA021704LD01HU SLC6A6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.01% thimerosal，50% glycerol，pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
  • 基因功能参考文献：
    1. TauT gene expression is significantly upregulated in mononuclear leukocytes of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine. PMID: 26955642
    2. CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy PMID: 26206726
    3. This is the first study to present information on the transcriptional regulation of taurine transporter gene and the localization of the taurine transporter protein in chondrocytic cells. PMID: 25501278
    4. Neurotransmitter transporters including SLC6A6 and SLC6A13 mediate the uptake of 5-aminolevulinic acid (ALA) and can play roles in the enhancement of ALA-induced accumulation of protoporphyrin in cancerous cells. PMID: 24842606
    5. Immunocytochemistry and flow cytometry analyses revealed that these mAbs recognized the native form of the extracellular domain of SLC6A6 on the cell surface. PMID: 24866236
    6. Taurine transporter is a novel pathological marker for stressed motor neurons in amyotrophic lateral sclerosis. PMID: 23180277
    7. Taurine transporter deficiency results in aberrant trophoblast turnover and fetal growth restriction. PMID: 23519128
    8. Syncytiotrophoblast TauT activity is reduced in maternal obesity and pre-eclampsia compared to normal pregnancy. PMID: 23392873
    9. Knockdown of TauT impairs kidney development, possibly through regulation of cell cycle-related genes. PMID: 23392892
    10. TauT gene is overexpressed in peripheral blood mononuclear cells of type 2 diabetic patients. PMID: 21739148
    11. TNF-alpha-treated cells showed a higher mRNA level of the TAUT (taurine transporter) than did the control cells. PMID: 12062416
    12. TauT is involved with p53 in renal development and apoptosis. PMID: 12163498
    13. regulation by WT1 PMID: 12681485
    14. nitric oxide plays an important role in downregulating microvillous plasma membrane taurine transporter activity in intrauterine growth restriction PMID: 15166008
    15. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca(2+)/CaM kinase II inhibitor. PMID: 15225620
    16. TAUT activity in TNF-alpha-treated Caco-2 cells suggests that up-regulation was associated with an increase in the amount of TAUT. PMID: 15630186
    17. reporter assay revealed that TNF-alpha-induced TAUT transcriptional activity through the NF-kappaB consensus-like sequence in the human TAUT promoter region PMID: 15907840
    18. taurine cotransporter is regulated by oxidative stress and overexpression of aldose reductase and high glucose impair this response PMID: 16356117
    19. Greater system beta activity in fetal platelets compared with T lymphocytes is the result of relatively greater TAUT mRNA and protein expression. PMID: 16956961
    20. Report taurine transporter activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
    21. This study demonstrates the functional coexpression of TauT along with the PAT1 transporter (SLC36A1) at the apical membrane of the intestinal epithelium. PMID: 19074966
    22. critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway PMID: 19423693
    23. Glucose reduced taurine transporter (TauT) mRNA and protein in a dose-dependent manner. PMID: 19602579

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A6 subfamily
  • 组织特异性：
    Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver.
  • 数据库链接：

    HGNC: 11052

    OMIM: 186854

    KEGG: hsa:6533

    STRING: 9606.ENSP00000354107

    UniGene: Hs.529488