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SLC15A2 Antibody

  • 货号：
    CSB-PA262561
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA262561(SLC15A2 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q16348
  • 基因名：
    SLC15A2
  • 别名：
    FLJ33407 antibody; Hydrogen ion/peptide cotransporter; kidney antibody; Kidney H(+)/peptide cotransporter antibody; kidney isoform antibody; Oligopeptide transporter antibody; Oligopeptide transporter kidney isoform antibody; PEPT2 antibody; Peptide transporter 2 antibody; S15A2_HUMAN antibody; Slc15a2 antibody; Solute carrier family 15 (H+/peptide transporter) member 2 antibody; solute carrier family 15 (oligopeptide transporter); member 2 antibody; Solute carrier family 15 member 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human SLC15A2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports the dipeptide-like aminopeptidase inhibitor bestatin. Can also transport the aminocephalosporin antibiotic cefadroxil. Also able to transport carnosine. Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand.
  • 基因功能参考文献：
    1. PEPT2 is expressed in keratinocytes and involved in skin oligopeptide uptake. PMID: 27216463
    2. PEPT2 is functionally expressed in H441 cells, making the cell line a good in vitro model to study PEPT2 function and its regulation in human distal lung. PMID: 26168863
    3. In vitro study displayed different response to sorafenib depending on the genotype of SLC15A2. PMID: 25965825
    4. This study showed that ALAD2 and hPEPT2*2 may be valuable markers of risk, and indicate novel mechanisms of lead-induced neurotoxicity PMID: 25514583
    5. LNCaP expresses high levels of PEPT2 and PHT1. PMID: 22950754
    6. ALAD2 and hPEPT2*2 polymorphisms may exaggerate Pb blood burden in boys. PMID: 21327641
    7. PepT2-mRNA is expressed in U373-MG and glial cells but showed no regulation of PepT2-mRNA expression in both cell types. PMID: 20868728
    8. Data identify Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated transporters. PMID: 20406817
    9. anserine is recognized by the proton-coupled peptide transporters PEPT1 and PEPT2 with medium affinity. Anserine is able to displace other substrates from the transport process. PMID: 20067523
    10. Higher blood lead burden in children with the PEPT2*2 mutation may suggest that this common genetic variant is a biomarker of increased vulnerability to the neurotoxic effects of lowest level lead exposure. PMID: 19723536
    11. expression, localization and functional aspects of this protein in the normal respiratory tract and in cystic fibrosis PMID: 12579467
    12. Amino acid substitution at Arg57 in PEPT2 causes a complete loss of transport function. PMID: 15020234
    13. polymorphisms in the gene encoding hPEPT2 can alter substrate transport and therefore could affect drug disposition in vivo PMID: 15282265
    14. expression and function of the peptide transporter PepT2 (SLC15A2) in differentiated primary cultures of upper airway lung epithelia PMID: 15626774
    15. PEPT2-PDZK1 interaction thus plays a physiologically important role in both oligopeptide handling as well as peptide-like drug transport in the human kidney PMID: 16738539
    16. does not operate as a cotransporter in tissues where there is little or no pH gradient, such as choroid plexus, lung, or mammary gland PMID: 18367661
    17. PEPT2 plays a vital role in microbial recognition by nucleotide-binding oligomerization domain (NOD)-like receptor proteins PMID: 18474668
    18. PEPT2 to be the dominant transporter for the reabsorption of di- and tripeptides and its pharmacological substrates in the organism, and for the removal of these substrates from the cerebrospinal fluid PMID: 18668438
    19. the expression/activity of PEPT2 may be a critical factor in the modulation of opioidergic neurotransmission in vivo. PMID: 18762712
    20. PEPT2 polymorphism distributions differ significantly between Chinese, Malay and Asian Indian populations. Cephalexin pharmacokinetics were not different between Chinese and Asian Indians. PMID: 18766334
    21. hPEPT1 and hPEPT2 are unlikely to contribute to clinically important drug interactions in humans. PMID: 19246733

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PTR2/POT transporter (TC 2.A.17) family
  • 组织特异性：
    Expressed in kidney. Not detected in intestine.
  • 数据库链接：

    HGNC: 10921

    OMIM: 602339

    KEGG: hsa:6565

    STRING: 9606.ENSP00000417085

    UniGene: Hs.518089