Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Solute carrier family 15 member 2 (SLC15A2), partial

Recombinant Human Solute carrier family 15 member 2 (SLC15A2), partial

  • 货号：
    CSB-YP623072HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP623072HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP623072HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP623072HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP623072HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC15A2
  • Uniprot No.：
  • 别名：
    FLJ33407; Hydrogen ion/peptide cotransporter; kidney; Kidney H(+)/peptide cotransporter; kidney isoform; Oligopeptide transporter; Oligopeptide transporter kidney isoform; PEPT2; Peptide transporter 2; S15A2_HUMAN; Slc15a2; Solute carrier family 15 (H+/peptide transporter) member 2; solute carrier family 15 (oligopeptide transporter); member 2; Solute carrier family 15 member 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports the dipeptide-like aminopeptidase inhibitor bestatin. Can also transport the aminocephalosporin antibiotic cefadroxil. Also able to transport carnosine. Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand.
  • 基因功能参考文献：
    1. PEPT2 is expressed in keratinocytes and involved in skin oligopeptide uptake. PMID: 27216463
    2. PEPT2 is functionally expressed in H441 cells, making the cell line a good in vitro model to study PEPT2 function and its regulation in human distal lung. PMID: 26168863
    3. In vitro study displayed different response to sorafenib depending on the genotype of SLC15A2. PMID: 25965825
    4. This study showed that ALAD2 and hPEPT2*2 may be valuable markers of risk, and indicate novel mechanisms of lead-induced neurotoxicity PMID: 25514583
    5. LNCaP expresses high levels of PEPT2 and PHT1. PMID: 22950754
    6. ALAD2 and hPEPT2*2 polymorphisms may exaggerate Pb blood burden in boys. PMID: 21327641
    7. PepT2-mRNA is expressed in U373-MG and glial cells but showed no regulation of PepT2-mRNA expression in both cell types. PMID: 20868728
    8. Data identify Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated transporters. PMID: 20406817
    9. anserine is recognized by the proton-coupled peptide transporters PEPT1 and PEPT2 with medium affinity. Anserine is able to displace other substrates from the transport process. PMID: 20067523
    10. Higher blood lead burden in children with the PEPT2*2 mutation may suggest that this common genetic variant is a biomarker of increased vulnerability to the neurotoxic effects of lowest level lead exposure. PMID: 19723536
    11. expression, localization and functional aspects of this protein in the normal respiratory tract and in cystic fibrosis PMID: 12579467
    12. Amino acid substitution at Arg57 in PEPT2 causes a complete loss of transport function. PMID: 15020234
    13. polymorphisms in the gene encoding hPEPT2 can alter substrate transport and therefore could affect drug disposition in vivo PMID: 15282265
    14. expression and function of the peptide transporter PepT2 (SLC15A2) in differentiated primary cultures of upper airway lung epithelia PMID: 15626774
    15. PEPT2-PDZK1 interaction thus plays a physiologically important role in both oligopeptide handling as well as peptide-like drug transport in the human kidney PMID: 16738539
    16. does not operate as a cotransporter in tissues where there is little or no pH gradient, such as choroid plexus, lung, or mammary gland PMID: 18367661
    17. PEPT2 plays a vital role in microbial recognition by nucleotide-binding oligomerization domain (NOD)-like receptor proteins PMID: 18474668
    18. PEPT2 to be the dominant transporter for the reabsorption of di- and tripeptides and its pharmacological substrates in the organism, and for the removal of these substrates from the cerebrospinal fluid PMID: 18668438
    19. the expression/activity of PEPT2 may be a critical factor in the modulation of opioidergic neurotransmission in vivo. PMID: 18762712
    20. PEPT2 polymorphism distributions differ significantly between Chinese, Malay and Asian Indian populations. Cephalexin pharmacokinetics were not different between Chinese and Asian Indians. PMID: 18766334
    21. hPEPT1 and hPEPT2 are unlikely to contribute to clinically important drug interactions in humans. PMID: 19246733

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PTR2/POT transporter (TC 2.A.17) family
  • 组织特异性：
    Expressed in kidney. Not detected in intestine.
  • 数据库链接：

    HGNC: 10921

    OMIM: 602339

    KEGG: hsa:6565

    STRING: 9606.ENSP00000417085

    UniGene: Hs.518089