Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. SKA2 Antibody

SKA2 Antibody

  • 货号：
    CSB-PA823890LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA823890LA01HU diluted at 1:400 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA823890LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SKA2 Polyclonal antibody
  • Uniprot No.：
    Q8WVK7
  • 基因名：
    SKA2
  • 别名：
    FAM33A antibody; Family with sequence similarity 33; member A antibody; FLJ12758 antibody; MGC110975 antibody; Protein FAM33A antibody; SKA 2 antibody; SKA2 antibody; SKA2_HUMAN antibody; Spindle and kinetochore associated complex subunit 2 antibody; Spindle and kinetochore associated protein 2 antibody; Spindle and kinetochore-associated protein 2 antibody; Spindle and KT (kinetochore) associated 2 antibody; Spindle and KT associated 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Spindle and kinetochore-associated protein 2 protein (1-121AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SKA2 Antibody (CSB-PA823890LA01HU)，的标记方式是Non-conjugated。对于SKA2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA823890LB01HU SKA2 Antibody, HRP conjugated ELISA
    FITC CSB-PA823890LC01HU SKA2 Antibody, FITC conjugated
    Biotin CSB-PA823890LD01HU SKA2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
  • 基因功能参考文献：
    1. decreased neuronal cell SKA complex genes' expression levels affect neuronal cell viability and neurite development PMID: 29268205
    2. study shows that decreased gene and protein expression of SKA2 observed in the prefrontal cortex of suicide victims is specific to suicide, which was not observed in the brain of nonsuicidal patients. It also indicates reduced SKA2 expression in suicide is independent of psychiatric diagnosis, since it is observed in all diagnostic groups studied. PMID: 26902949
    3. Possible association between SKA2 expression in prefrontal cortex and MDD. PMID: 27030168
    4. Data show that HOTAIR might act as an endogenous 'sponge' of miR-141, thereby regulating the derepression of SKA2. PMID: 27121316
    5. The study adds evidence that CREB, a tumor oncogene, promotes renal cell carcinoma proliferation. It probably achieves this by increasing SKA2 expression PMID: 26824422
    6. Kinetochores mature through Ska1/ska2/Ska3 complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint. PMID: 28495837
    7. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
    8. these data establish the importance of SKA2 for cortisol stress responsivity and the development of post-traumatic stress disorder and provide further evidence that SKA2 is a promising biomarker for stress-related disorders including PTSD. PMID: 26361058
    9. Results suggest that DNA methylation(adj) of SKA2 in blood indexes stress-related psychiatric phenotypes and neurobiology, pointing to its potential value as a biomarker of stress exposure and susceptibility. PMID: 26324104
    10. DNA methylation of the SKA2 gene has been implicated as a biomarker of suicide risk and posttraumatic stress disorder. PMID: 27038412
    11. SKA2 is hypothesized to reduce the ability to suppress cortisol following stress. PMID: 26305478
    12. PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells PMID: 26162986
    13. SKA2 significantly interacted with anxiety and stress to explain about 80% of suicidal behavior and progression from suicidal ideation to suicide attempt.SKA2 is a novel genetic and epigenetic marker involved in the etiology of suicide, suicidal behaviors PMID: 25073599
    14. The structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1, Ska2, and Ska3. PMID: 22483620
    15. Data suggest that Aurora B phosphorylation antagonizes the interaction between the Ska1-3 complex and the KMN network, thereby controlling Ska recruitment to KTs and stabilization of KT-MT attachments. PMID: 22371557
    16. blocking of miR-301 in A549 cells leads to a decrease in the expression of the host gene, ska2. PMID: 20470754
    17. These data suggest that the Ska1/Ska2 complex plays a critical role in the maintenance of the metaphase plate and/or spindle checkpoint silencing. PMID: 17093495
    18. Study discovered that FAM33A is protein partners for GRs and is involved in cell proliferation and GC signalling. PMID: 18583474

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    SKA2 family
  • 数据库链接：

    HGNC: 28006

    OMIM: 616674

    KEGG: hsa:348235

    STRING: 9606.ENSP00000333433

    UniGene: Hs.463607