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SHC4 Antibody

  • 货号：
    CSB-PA747568ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA747568ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SHC4 Polyclonal antibody
  • Uniprot No.：
    Q6S5L8
  • 基因名：
  • 别名：
    hShcD antibody; MGC34023 antibody; Rai like protein antibody; Rai-like protein antibody; RaLP antibody; SH2 domain protein C4 antibody; SHC (Src homology 2 domain containing) family member 4 antibody; SHC 4 antibody; SHC adaptor protein 4 antibody; SHC antibody; SHC family member 4 antibody; SHC transforming protein 4 antibody; SHC transforming protein D antibody; SHC-transforming protein 4 antibody; SHC-transforming protein D antibody; Shc4 antibody; SHC4_HUMAN antibody; SHCD antibody; Src homology 2 domain containing family member 4 antibody; Src homology 2 domain containing transforming protein C4 antibody; Src homology 2 domain-containing-transforming protein C4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human SHC-transforming protein 4 protein (1-185AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
  • 基因功能参考文献：
    1. ShcD appears to possess several molecular permutations that actively govern the EGFR, which may have implications in development and disease. PMID: 28724758
    2. ShcD binds to active Ret, TrkA, and TrkB neurotrophic factor receptors predominantly via its phosphotyrosine-binding (PTB) domain. PMID: 28213521
    3. The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. PMID: 24430869
    4. ShcD can exist within the nucleus, and its CH2 domain has a critical role in nuclear export of ShcD. PMID: 24036217
    5. ShcD binds to TrkC in a kinase-activity-dependent manner through its PTB and SH2 domains. PMID: 20078941
    6. ShcD interacts with TrkB in a kinase-activity-dependent manner. PMID: 20663410
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    8. A new member of the Shc family of docking proteins is characterised, which may mediate a specific aspect of signaling downstream of the MuSK receptor. PMID: 17452444

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane.
  • 组织特异性：
    Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive
  • 数据库链接：

    HGNC: 16743

    OMIM: 617372

    KEGG: hsa:399694

    STRING: 9606.ENSP00000329668

    UniGene: Hs.642615