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  4. Recombinant Human SHC-transforming protein 4 (SHC4)

Recombinant Human SHC-transforming protein 4 (SHC4)

  • 中文名称：
    人SHC4重组蛋白
  • 货号：
    CSB-YP747568HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SHC4重组蛋白
  • 货号：
    CSB-EP747568HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SHC4重组蛋白
  • 货号：
    CSB-EP747568HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SHC4重组蛋白
  • 货号：
    CSB-BP747568HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SHC4重组蛋白
  • 货号：
    CSB-MP747568HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    hShcD; MGC34023; Rai like protein; Rai-like protein; RaLP; SH2 domain protein C4; SHC (Src homology 2 domain containing) family member 4; SHC 4; SHC adaptor protein 4; SHC; SHC family member 4; SHC transforming protein 4; SHC transforming protein D; SHC-transforming protein 4; SHC-transforming protein D; Shc4; SHC4_HUMAN; SHCD; Src homology 2 domain containing family member 4; Src homology 2 domain containing transforming protein C4; Src homology 2 domain-containing-transforming protein C4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-630
  • 氨基酸序列
    MRERGQDSLA GLVLYVGLFG HPGMLHRAKY SRFRNESITS LDEGSSGGSV GNKGSPQPPH PALAPHLPTE DATLPSQESP TPLCTLIPRM ASMKLANPAT LLSLKNFCLG TKEVPRLKLQ ESRDPGSSGP SSPETSLSRS GTAPPPQQDL VGHRATALTP DSCPLPGPGE PTLRSRQDRH FLQHLLGMGM NYCVRYMGCV EVLQSMRSLD FGMRTQVTRE AISRLCEAVP GANGAIKKRK PPVKFLSTVL GKSNLQFSGM NIKLTISTCS LTLMNLDNQQ IIANHHMQSI SFASGGDPDT TDYVAYVAKD PVNQRACHIL ECHNGMAQDV ISTIGQAFEL RFKQYLKNPS LNTSCESEEV HIDSHAEERE DHEYYNEIPG KQPPVGGVSD MRIKVQATEQ MAYCPIQCEK LCYLPGNSKC SSVYENCLEQ SRAIGNVHPR GVQSQRDTSL LKHTCRVDLF DDPCYINTQA LQSTPGSAGN QRSAQPLGSP WHCGKAPETV QPGATAQPAS SHSLPHIKQQ LWSEECYHGK LSRKAAESLL VKDGDFLVRE SATSPGQYVL SGLQGGQAKH LLLVDPEGKV RTKDHVFDNV GHLIRYHMDN SLPIISSGSE VSLKQPVRKD NNPALLHSNK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
  • 基因功能参考文献：
    1. ShcD appears to possess several molecular permutations that actively govern the EGFR, which may have implications in development and disease. PMID: 28724758
    2. ShcD binds to active Ret, TrkA, and TrkB neurotrophic factor receptors predominantly via its phosphotyrosine-binding (PTB) domain. PMID: 28213521
    3. The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. PMID: 24430869
    4. ShcD can exist within the nucleus, and its CH2 domain has a critical role in nuclear export of ShcD. PMID: 24036217
    5. ShcD binds to TrkC in a kinase-activity-dependent manner through its PTB and SH2 domains. PMID: 20078941
    6. ShcD interacts with TrkB in a kinase-activity-dependent manner. PMID: 20663410
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    8. A new member of the Shc family of docking proteins is characterised, which may mediate a specific aspect of signaling downstream of the MuSK receptor. PMID: 17452444

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane.
  • 组织特异性：
    Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive
  • 数据库链接：

    HGNC: 16743

    OMIM: 617372

    KEGG: hsa:399694

    STRING: 9606.ENSP00000329668

    UniGene: Hs.642615