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SEMA3B Antibody

  • 货号：
    CSB-PA622646ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA622646ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SEMA3B Polyclonal antibody
  • Uniprot No.：
    Q13214
  • 基因名：
  • 别名：
    SEM3B_HUMAN antibody; Sema A(V) antibody; Sema V antibody; Sema3b antibody; Semaphorin V antibody; Semaphorin-3B antibody; Semaphorin-V antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Semaphorin-3B protein (570-749AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
  • 基因功能参考文献：
    1. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. PMID: 29763494
    2. data provide new insights into the role of SEMA3B in mammary gland and provides a new branch of GATA3 signaling that is pivotal for inhibition of breast cancer progression and metastasis PMID: 28581515
    3. By upregulating p53 and p21 expression and inhibiting Akt (Ser473) phosphorylation, SEMA3B could induce cell cycle arrest at G1/S phase. PMID: 27349960
    4. As the clinical pathological glioma grade increased, SEMA3B expression decreased. PMID: 27050958
    5. Maternal SEMA 3B level increased in preeclampsia before the onset of manifestations, indicating that SEMA 3B plays a role in the pathogenesis of preeclampsia PMID: 26828533
    6. Aberrant expression and methylation of SEMA3B could be suggested as markers of lung and renal cancer progression. PMID: 25961819
    7. although plexin-A4 overexpression restored Sema3A signaling in plexin-A1-silenced cells, it failed to restore Sema3B signaling in plexin-A2-silenced cells. PMID: 25335892
    8. SEMA3B mRNA and protein is not altered in severe early onset preeclamptic placentas. PMID: 25454475
    9. CpG methylation of SEMA3B epigenetically regulates SEMA3B expression during development of gastric cancer. PMID: 24402303
    10. The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors. PMID: 24280143
    11. Three candidate tumor-suppressor genes, SEMA3B, AXUD1 and GNAT1 may be involved in oral squamous cell carcinoma. PMID: 23292452
    12. Loss of Sema3B expression is associated with biochemical recurrence of patients with low- and intermediate-risk prostate cancer. PMID: 23906303
    13. semaphorin-3B and semaphorin-3F have roles in ovarian cancer PMID: 20124444
    14. that methylation of promoter CpG-island contributed into inactivation of SEMA3B gene-suppressor in RCC. PMID: 20088387
    15. Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. PMID: 11809707
    16. SEMA3B gene alterations may play a important role in the malignant transformation of NSCLC via a two-hit mechanism, including epigenetic changes and allelic loss, for tumor suppressor gene inactivation. PMID: 12810670
    17. Heterozygous or homozygous variant genotype confers a >40% reduced relative risk of lung cancer in Latino Americans controlling for other lung cancer risk factors. PMID: 15831529
    18. Higher level of SEMA3B expression was found in differentiated tumors with favorable histopathology (n = 19) than in tumors with unfavorable histology. PMID: 17452250
    19. A putative role for SEMA3B as an osteoblast protein that regulates bone mass and skeletal homeostasis. PMID: 18356290
    20. SEMA3B exerts unexpected functions in cancer progression by fostering a prometastatic environment through elevated IL-8 secretion. PMID: 18458115
    21. Repulsion of human umbilical vascular endothelial cells by sema3B-m was mediated primarily by the neuropilin-1 receptor but sema3B-m was also able to transduce signals via neuropilin-2 PMID: 18757406
    22. SEMA3B is a potential tumor suppressor that induces apoptosis in SEMA3B-inactivated tumor cells through the Np-1 receptor by inactivating the Akt signaling pathway. PMID: 18922901
    23. IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. PMID: 18985860
    24. SEMA3B plays role in inhibiting of growth of renal, ovarian and colorectal cancer cells. PMID: 19548530
    25. These data indicate that polymorphisms in SEMA3B are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men PMID: 19683737
    26. Identification of semaphorin 3B as a direct target of p53. PMID: 11922394

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  • 亚细胞定位：
    Secreted. Endoplasmic reticulum. Note=Accumulates in the endoplasmic reticulum.
  • 蛋白家族：
    Semaphorin family
  • 组织特异性：
    Expressed abundantly but differentially in a variety of neural and nonneural tissues.
  • 数据库链接：

    HGNC: 10724

    OMIM: 601281

    KEGG: hsa:7869

    UniGene: Hs.82222