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  4. Recombinant Human Semaphorin-3B (SEMA3B)

Recombinant Human Semaphorin-3B (SEMA3B)

  • 货号：
    CSB-YP622646HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP622646HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-MP622646HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    SEM3B_HUMAN; Sema A(V); Sema V; Sema3b; Semaphorin V; Semaphorin-3B; Semaphorin-V
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-749
  • 氨基酸序列
    APSPPR LRLSFQELQA WHGLQTFSLE RTCCYQALLV DEERGRLFVG AENHVASLNL DNISKRAKKL AWPAPVEWRE ECNWAGKDIG TECMNFVKLL HAYNRTHLLA CGTGAFHPTC AFVEVGHRAE EPVLRLDPGR IEDGKGKSPY DPRHRAASVL VGEELYSGVA ADLMGRDFTI FRSLGQRPSL RTEPHDSRWL NEPKFVKVFW IPESENPDDD KIYFFFRETA VEAAPALGRL SVSRVGQICR NDVGGQRSLV NKWTTFLKAR LVCSVPGVEG DTHFDQLQDV FLLSSRDHRT PLLYAVFSTS SSIFQGSAVC VYSMNDVRRA FLGPFAHKEG PMHQWVSYQG RVPYPRPGMC PSKTFGTFSS TKDFPDDVIQ FARNHPLMYN SVLPTGGRPL FLQVGANYTF TQIAADRVAA ADGHYDVLFI GTDVGTVLKV ISVPKGSRPS AEGLLLEELH VFEDSAAVTS MQISSKRHQL YVASRSAVAQ IALHRCAAHG RVCTECCLAR DPYCAWDGVA CTRFQPSAKR RFRRQDVRNG DPSTLCSGDS SRPALLEHKV FGVEGSSAFL ECEPRSLQAR VEWTFQRAGV TAHTQVLAEE RTERTARGLL LRRLRRRDSG VYLCAAVEQG FTQPLRRLSL HVLSATQAER LARAEEAAPA APPGPKLWYR DFLQLVEPGG GGSANSLRMC RPQPALQSLP LESRRKGRNR RTHAPEPRAE RGPRSATHW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
  • 基因功能参考文献：
    1. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. PMID: 29763494
    2. data provide new insights into the role of SEMA3B in mammary gland and provides a new branch of GATA3 signaling that is pivotal for inhibition of breast cancer progression and metastasis PMID: 28581515
    3. By upregulating p53 and p21 expression and inhibiting Akt (Ser473) phosphorylation, SEMA3B could induce cell cycle arrest at G1/S phase. PMID: 27349960
    4. As the clinical pathological glioma grade increased, SEMA3B expression decreased. PMID: 27050958
    5. Maternal SEMA 3B level increased in preeclampsia before the onset of manifestations, indicating that SEMA 3B plays a role in the pathogenesis of preeclampsia PMID: 26828533
    6. Aberrant expression and methylation of SEMA3B could be suggested as markers of lung and renal cancer progression. PMID: 25961819
    7. although plexin-A4 overexpression restored Sema3A signaling in plexin-A1-silenced cells, it failed to restore Sema3B signaling in plexin-A2-silenced cells. PMID: 25335892
    8. SEMA3B mRNA and protein is not altered in severe early onset preeclamptic placentas. PMID: 25454475
    9. CpG methylation of SEMA3B epigenetically regulates SEMA3B expression during development of gastric cancer. PMID: 24402303
    10. The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors. PMID: 24280143
    11. Three candidate tumor-suppressor genes, SEMA3B, AXUD1 and GNAT1 may be involved in oral squamous cell carcinoma. PMID: 23292452
    12. Loss of Sema3B expression is associated with biochemical recurrence of patients with low- and intermediate-risk prostate cancer. PMID: 23906303
    13. semaphorin-3B and semaphorin-3F have roles in ovarian cancer PMID: 20124444
    14. that methylation of promoter CpG-island contributed into inactivation of SEMA3B gene-suppressor in RCC. PMID: 20088387
    15. Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. PMID: 11809707
    16. SEMA3B gene alterations may play a important role in the malignant transformation of NSCLC via a two-hit mechanism, including epigenetic changes and allelic loss, for tumor suppressor gene inactivation. PMID: 12810670
    17. Heterozygous or homozygous variant genotype confers a >40% reduced relative risk of lung cancer in Latino Americans controlling for other lung cancer risk factors. PMID: 15831529
    18. Higher level of SEMA3B expression was found in differentiated tumors with favorable histopathology (n = 19) than in tumors with unfavorable histology. PMID: 17452250
    19. A putative role for SEMA3B as an osteoblast protein that regulates bone mass and skeletal homeostasis. PMID: 18356290
    20. SEMA3B exerts unexpected functions in cancer progression by fostering a prometastatic environment through elevated IL-8 secretion. PMID: 18458115
    21. Repulsion of human umbilical vascular endothelial cells by sema3B-m was mediated primarily by the neuropilin-1 receptor but sema3B-m was also able to transduce signals via neuropilin-2 PMID: 18757406
    22. SEMA3B is a potential tumor suppressor that induces apoptosis in SEMA3B-inactivated tumor cells through the Np-1 receptor by inactivating the Akt signaling pathway. PMID: 18922901
    23. IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. PMID: 18985860
    24. SEMA3B plays role in inhibiting of growth of renal, ovarian and colorectal cancer cells. PMID: 19548530
    25. These data indicate that polymorphisms in SEMA3B are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men PMID: 19683737
    26. Identification of semaphorin 3B as a direct target of p53. PMID: 11922394

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  • 亚细胞定位：
    Secreted. Endoplasmic reticulum. Note=Accumulates in the endoplasmic reticulum.
  • 蛋白家族：
    Semaphorin family
  • 组织特异性：
    Expressed abundantly but differentially in a variety of neural and nonneural tissues.
  • 数据库链接：

    HGNC: 10724

    OMIM: 601281

    KEGG: hsa:7869

    UniGene: Hs.82222