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SCG5 Antibody

  • 货号：
    CSB-PA020810DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SCG5 Polyclonal antibody
  • Uniprot No.：
    P05408
  • 基因名：
    SCG5
  • 别名：
    SCG5 antibody; SGNE1Neuroendocrine protein 7B2 antibody; Pituitary polypeptide antibody; Secretogranin V antibody; Secretogranin-5 antibody; Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Neuroendocrine protein 7B2 protein (27-212AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
  • 基因功能参考文献：
    1. Describe a hereditary mixed polyposis syndrome in which is characterized by SCG5-GREM1 duplication. PMID: 27984123
    2. FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing. PMID: 25811241
    3. 7B2 chaperones blocked the cytotoxic effects of exogenous hIAPP PMID: 24042052
    4. conclude that 7B2 is a natively disordered protein whose function as an antiaggregant chaperone is likely facilitated by its lack of appreciable secondary structure and tendency to form oligomers PMID: 22947085
    5. data provide insight into novel functions of 7B2 and establish this neural protein as an anti-aggregation chaperone associated with neurodegenerative disease PMID: 23172224
    6. the significant effects of SGNE1/7B2 on the growth and apoptosis of glioblastoma cells provide a first proof for a functional implication of SGNE1/7B2 inactivation in the molecular pathology of gliomas. PMID: 21901745
    7. SGNE1 was overexpressed in gastrointestinal peptide-independent ACTH-independent macronodular adrenal hyperplasia. hyperplasia PMID: 14767469
    8. SGNE1 identified as a novel epigenetically silenced gene in medulloblastomas and its inactivation, as well as its inhibitory effect on tumor cell proliferation and focus formation strongly argues for a significant role in medulloblastoma development. PMID: 17334394
    9. SGNE1 genetic variation does not contribute to obesity and common forms of Type 2 diabetes but may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity PMID: 17617923
    10. Secretogranins V assays failed to detect increased concentrations in any of the patients with neuroendocrine tumours. PMID: 18448176

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  • 亚细胞定位：
    Secreted. Note=Neuroendocrine and endocrine secretory granules.
  • 蛋白家族：
    7B2 family
  • 数据库链接：

    HGNC: 10816

    OMIM: 173120

    KEGG: hsa:6447

    STRING: 9606.ENSP00000300175

    UniGene: Hs.156540