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  4. Recombinant Human Neuroendocrine protein 7B2 (SCG5), partial

Recombinant Human Neuroendocrine protein 7B2 (SCG5), partial

  • 中文名称：
    人SCG5重组蛋白
  • 货号：
    CSB-YP020810HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SCG5重组蛋白
  • 货号：
    CSB-EP020810HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SCG5重组蛋白
  • 货号：
    CSB-EP020810HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SCG5重组蛋白
  • 货号：
    CSB-BP020810HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SCG5重组蛋白
  • 货号：
    CSB-MP020810HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SCG5
  • Uniprot No.：
  • 别名：
    SCG5; SGNE1Neuroendocrine protein 7B2; Pituitary polypeptide; Secretogranin V; Secretogranin-5; Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 表达区域：
    27-176aa
  • 氨基酸序列
    YSPRTPDRVSEADIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPVGKTADDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
  • 基因功能参考文献：
    1. Describe a hereditary mixed polyposis syndrome in which is characterized by SCG5-GREM1 duplication. PMID: 27984123
    2. FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing. PMID: 25811241
    3. 7B2 chaperones blocked the cytotoxic effects of exogenous hIAPP PMID: 24042052
    4. conclude that 7B2 is a natively disordered protein whose function as an antiaggregant chaperone is likely facilitated by its lack of appreciable secondary structure and tendency to form oligomers PMID: 22947085
    5. data provide insight into novel functions of 7B2 and establish this neural protein as an anti-aggregation chaperone associated with neurodegenerative disease PMID: 23172224
    6. the significant effects of SGNE1/7B2 on the growth and apoptosis of glioblastoma cells provide a first proof for a functional implication of SGNE1/7B2 inactivation in the molecular pathology of gliomas. PMID: 21901745
    7. SGNE1 was overexpressed in gastrointestinal peptide-independent ACTH-independent macronodular adrenal hyperplasia. hyperplasia PMID: 14767469
    8. SGNE1 identified as a novel epigenetically silenced gene in medulloblastomas and its inactivation, as well as its inhibitory effect on tumor cell proliferation and focus formation strongly argues for a significant role in medulloblastoma development. PMID: 17334394
    9. SGNE1 genetic variation does not contribute to obesity and common forms of Type 2 diabetes but may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity PMID: 17617923
    10. Secretogranins V assays failed to detect increased concentrations in any of the patients with neuroendocrine tumours. PMID: 18448176

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  • 亚细胞定位：
    Secreted. Note=Neuroendocrine and endocrine secretory granules.
  • 蛋白家族：
    7B2 family
  • 数据库链接：

    HGNC: 10816

    OMIM: 173120

    KEGG: hsa:6447

    STRING: 9606.ENSP00000300175

    UniGene: Hs.156540