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SAMSN1 Antibody

  • 货号：
    CSB-PA885722LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA885722LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SAMSN1 Polyclonal antibody
  • Uniprot No.：
    Q9NSI8
  • 基因名：
    SAMSN1
  • 别名：
    HACS1 antibody; Hematopoietic adapter containing SH3 and sterile α, motif (SAM) domains 1 antibody; Hematopoietic adapter containing SH3 and sterile alpha motif (SAM) domains 1 antibody; Hematopoietic adaptor containing SH3 and SAM domains 1 antibody; Nash1 antibody; Nuclear localization signals SAM and SH3 domain containing 1 antibody; SAM and SH3 domain containing 2 antibody; SAM domain antibody; SAM domain containing protein SAMSN 1 antibody; SAM domain SH3 domain and nuclear localisation signals 1 antibody; SAM domain SH3 domain and nuclear localization signals 1 antibody; SAM domain, SH3 domain and nuclear localization signals protein 1 antibody; SAM domain-containing protein SAMSN-1 antibody; SAMN1_HUMAN antibody; SAMSN 1 antibody; Samsn1 antibody; SASH2 antibody; SH3 domain and nuclear localisation signals 1 antibody; SH3 domain and nuclear localization signals protein 1 antibody; SH3 SAM adaptor protein antibody; SH3-SAM adaptor protein antibody; SH3D6B antibody; SLy2 antibody; Src homology domain 3 (SH3) containing adapter protein SH3 lymphocyte protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human SAM domain-containing protein SAMSN-1 protein (1-373AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SAMSN1 Antibody (CSB-PA885722LA01HU)，的标记方式是Non-conjugated。对于SAMSN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA885722LB01HU SAMSN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA885722LC01HU SAMSN1 Antibody, FITC conjugated
    Biotin CSB-PA885722LD01HU SAMSN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
  • 基因功能参考文献：
    1. Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma. PMID: 25805236
    2. This is the first study to identify deletion of a key gene in the C57BL/KaLwRij mice that also displays reduced gene expression in patients with MM and is therefore likely to play an integral role in MM disease development. PMID: 25117979
    3. High expression of SAMSN1 is a significant risk factor for the progression free and overall survival of glioblastoma multiforme PMID: 24278465
    4. the immunoinhibitory roles of SLy2 in vivo and suggest that the physiological up-regulation of SLy2 observed upon B cell activation functions to counteract excessive B cell spreading. PMID: 21296879
    5. In the nucleus, SLy2 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1. PMID: 20478393
    6. HACS1 is up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. PMID: 15381729
    7. downregulation of SAMSN1 gene in human lung cancer. PMID: 18523997

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection, ruffle.
  • 组织特异性：
    Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.
  • 数据库链接：

    HGNC: 10528

    OMIM: 607978

    KEGG: hsa:64092

    STRING: 9606.ENSP00000383411

    UniGene: Hs.473341