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  4. Recombinant Human SAM domain-containing protein SAMSN-1 (SAMSN1)

Recombinant Human SAM domain-containing protein SAMSN-1 (SAMSN1)

  • 中文名称：
    人SAMSN1重组蛋白
  • 货号：
    CSB-YP885722HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SAMSN1重组蛋白
  • 货号：
    CSB-EP885722HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SAMSN1重组蛋白
  • 货号：
    CSB-EP885722HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SAMSN1重组蛋白
  • 货号：
    CSB-BP885722HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SAMSN1重组蛋白
  • 货号：
    CSB-MP885722HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SAMSN1
  • Uniprot No.：
  • 别名：
    HACS1; Hematopoietic adapter containing SH3 and sterile α, motif (SAM) domains 1; Hematopoietic adapter containing SH3 and sterile alpha motif (SAM) domains 1; Hematopoietic adaptor containing SH3 and SAM domains 1; Nash1; Nuclear localization signals SAM and SH3 domain containing 1; SAM and SH3 domain containing 2; SAM domain; SAM domain containing protein SAMSN 1; SAM domain SH3 domain and nuclear localisation signals 1; SAM domain SH3 domain and nuclear localization signals 1; SAM domain, SH3 domain and nuclear localization signals protein 1; SAM domain-containing protein SAMSN-1; SAMN1_HUMAN; SAMSN 1; Samsn1; SASH2; SH3 domain and nuclear localisation signals 1; SH3 domain and nuclear localization signals protein 1; SH3 SAM adaptor protein; SH3-SAM adaptor protein; SH3D6B; SLy2; Src homology domain 3 (SH3) containing adapter protein SH3 lymphocyte protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-373
  • 氨基酸序列
    MLKRKPSNVS EKEKHQKPKR SSSFGNFDRF RNNSLSKPDD STEAHEGDPT NGSGEQSKTS NNGGGLGKKM RAISWTMKKK VGKKYIKALS EEKDEEDGEN AHPYRNSDPV IGTHTEKVSL KASDSMDSLY SGQSSSSGIT SCSDGTSNRD SFRLDDDGPY SGPFCGRARV HTDFTPSPYD TDSLKIKKGD IIDIICKTPM GMWTGMLNNK VGNFKFIYVD VISEEEAAPK KIKANRRSNS KKSKTLQEFL ERIHLQEYTS TLLLNGYETL EDLKDIKESH LIELNIENPD DRRRLLSAAE NFLEEEIIQE QENEPEPLSL SSDISLNKSQ LDDCPRDSGC YISSGNSDNG KEDLESENLS DMVHKIIITE PSD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
  • 基因功能参考文献：
    1. Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma. PMID: 25805236
    2. This is the first study to identify deletion of a key gene in the C57BL/KaLwRij mice that also displays reduced gene expression in patients with MM and is therefore likely to play an integral role in MM disease development. PMID: 25117979
    3. High expression of SAMSN1 is a significant risk factor for the progression free and overall survival of glioblastoma multiforme PMID: 24278465
    4. the immunoinhibitory roles of SLy2 in vivo and suggest that the physiological up-regulation of SLy2 observed upon B cell activation functions to counteract excessive B cell spreading. PMID: 21296879
    5. In the nucleus, SLy2 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1. PMID: 20478393
    6. HACS1 is up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. PMID: 15381729
    7. downregulation of SAMSN1 gene in human lung cancer. PMID: 18523997

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection, ruffle.
  • 组织特异性：
    Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.
  • 数据库链接：

    HGNC: 10528

    OMIM: 607978

    KEGG: hsa:64092

    STRING: 9606.ENSP00000383411

    UniGene: Hs.473341