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RPS27 Antibody

  • 货号：
    CSB-PA445027
  • 规格：
    ￥1100
  • 图片：
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, K562 cells, Raji cells, Primary antibody: CSB-PA445027(RPS27 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P42677
  • 基因名：
    RPS27
  • 别名：
    2610206D02Rik antibody; 3200001M24Rik antibody; 40S ribosomal protein S27 antibody; C530005D02Rik antibody; Metallopan stimulin 1 antibody; Metallopan-stimulin 1 antibody; Metallopanstimulin 1 antibody; Metallopanstimulin1 antibody; MPS 1 antibody; MPS-1 antibody; MPS1 antibody; pmn antibody; Ribosomal protein S27 antibody; Ribosomal protein S27 metallopanstimulin 1 antibody; rps27 antibody; RS27_HUMAN antibody; S27 antibody; snoRNA MBI 112 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human RPS27
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs.
  • 基因功能参考文献：
    1. Chloride anion behaves as a signaling effector for CFTR in the modulation of RPS27 expression. PMID: 28941802
    2. reveal how Mps1 dynamically modifies kinetochores to correct improper attachments and ensure faithful chromosome segregation PMID: 28441529
    3. MPS1 is a new marker of Purkinje Cells. PMID: 26708598
    4. We identified frequent recurrent (i.e. hotspot) mutation in the 5' untranslated region of RPS27 in ~10% of melanoma samples PMID: 24913145
    5. The data on genome context analysis indicates that the presence of MPS-1 in the blood is an indicator of oncogenesis PMID: 22798506
    6. This work is consistent with a critical role of RPMPS-1/S27 in the life cycle of various viruses and shows that disruption of viral ZFPs is potentially important to control and prevent deathly viral diseases PMID: 21518817
    7. study reveals a multilevel interplay between RPS27L/S27 and p53-MDM2 axis, with RPS27L functioning as a p53 target, a MDM2 substrate and a p53 regulator PMID: 21170087
    8. When MPS-1 is overexpressed, it has an extraribosomal function as a strong inhibitor of HNSCC tumor cell growth, which may be exerted by reduced paxillin gene expression. PMID: 19642098
    9. MPS-1 was overexpressed in 86% of the gastric cancer tissues and all gastric cancer cells. MPS-1 expression was significantly increased and corresponded with the tumor-node-metastasis clinical stage, and was significantly higher in the late stage. PMID: 16914586

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  • 相关疾病：
    Diamond-Blackfan anemia 17 (DBA17)
  • 蛋白家族：
    Eukaryotic ribosomal protein eS27 family
  • 组织特异性：
    Expressed in a wide variety of actively proliferating cells and tumor tissues.
  • 数据库链接：

    HGNC: 10416

    OMIM: 603702

    KEGG: hsa:6232

    STRING: 9606.ENSP00000357555

    UniGene: Hs.546291