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  4. Recombinant Human 40S ribosomal protein S27 (RPS27)

Recombinant Human 40S ribosomal protein S27 (RPS27)

  • 中文名称：
    人RPS27重组蛋白
  • 货号：
    CSB-EP020419HU
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    RPS27
  • Uniprot No.：
  • 别名：
    2610206D02Rik; 3200001M24Rik; 40S ribosomal protein S27; C530005D02Rik; Metallopan stimulin 1; Metallopan-stimulin 1; Metallopanstimulin 1; Metallopanstimulin1; MPS 1; MPS-1; MPS1; pmn; Ribosomal protein S27; Ribosomal protein S27 metallopanstimulin 1; rps27; RS27_HUMAN; S27; snoRNA MBI 112
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    36.3kDa
  • 表达区域：
    1-84aa
  • 氨基酸序列
    PLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs.
  • 基因功能参考文献：
    1. Chloride anion behaves as a signaling effector for CFTR in the modulation of RPS27 expression. PMID: 28941802
    2. reveal how Mps1 dynamically modifies kinetochores to correct improper attachments and ensure faithful chromosome segregation PMID: 28441529
    3. MPS1 is a new marker of Purkinje Cells. PMID: 26708598
    4. We identified frequent recurrent (i.e. hotspot) mutation in the 5' untranslated region of RPS27 in ~10% of melanoma samples PMID: 24913145
    5. The data on genome context analysis indicates that the presence of MPS-1 in the blood is an indicator of oncogenesis PMID: 22798506
    6. This work is consistent with a critical role of RPMPS-1/S27 in the life cycle of various viruses and shows that disruption of viral ZFPs is potentially important to control and prevent deathly viral diseases PMID: 21518817
    7. study reveals a multilevel interplay between RPS27L/S27 and p53-MDM2 axis, with RPS27L functioning as a p53 target, a MDM2 substrate and a p53 regulator PMID: 21170087
    8. When MPS-1 is overexpressed, it has an extraribosomal function as a strong inhibitor of HNSCC tumor cell growth, which may be exerted by reduced paxillin gene expression. PMID: 19642098
    9. MPS-1 was overexpressed in 86% of the gastric cancer tissues and all gastric cancer cells. MPS-1 expression was significantly increased and corresponded with the tumor-node-metastasis clinical stage, and was significantly higher in the late stage. PMID: 16914586

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  • 相关疾病：
    Diamond-Blackfan anemia 17 (DBA17)
  • 蛋白家族：
    Eukaryotic ribosomal protein eS27 family
  • 组织特异性：
    Expressed in a wide variety of actively proliferating cells and tumor tissues.
  • 数据库链接：

    HGNC: 10416

    OMIM: 603702

    KEGG: hsa:6232

    STRING: 9606.ENSP00000357555

    UniGene: Hs.546291