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RNASEH2A Antibody

  • 货号：
    CSB-PA019805GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O75792
  • 基因名：
    RNASEH2A
  • 别名：
    RNASEH2A antibody; RNASEHI antibody; RNHIA antibody; Ribonuclease H2 subunit A antibody; RNase H2 subunit A antibody; EC 3.1.26.4 antibody; Aicardi-Goutieres syndrome 4 protein antibody; AGS4 antibody; RNase H(35) antibody; Ribonuclease HI large subunit antibody; RNase HI large subunit antibody; Ribonuclease HI subunit A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RNASEH2A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
  • 基因功能参考文献：
    1. The expression levels of RNASEH2A, CDK1, and CD151 and their combination could predict the survival of renal cell carcinoma patients. PMID: 29843367
    2. RNaseH2A may be involved in human gliomagenesis. PMID: 27176716
    3. This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2A in patients with Aicardi-Goutieres Syndrome. PMID: 27643693
    4. RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner. PMID: 24986920
    5. Studies indicate that most antiviral-defense systems involve RNase H-like enzymes destroying invading nucleic acids, RNA, or DNA. PMID: 25703292
    6. study identified two synonymous variants in RNASEH2A that result in loss of RNase H2 enzyme function and the consequent Aicardi-Goutieres syndrome phenotype PMID: 23592335
    7. analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome PMID: 21454563

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  • 相关疾病：
    Aicardi-Goutieres syndrome 4 (AGS4)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RNase HII family, Eukaryotic subfamily
  • 数据库链接：

    HGNC: 18518

    OMIM: 606034

    KEGG: hsa:10535

    STRING: 9606.ENSP00000221486

    UniGene: Hs.532851