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  4. Recombinant Human Ribonuclease H2 subunit A (RNASEH2A)

Recombinant Human Ribonuclease H2 subunit A (RNASEH2A)

  • 货号：
    CSB-YP019805HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019805HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019805HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019805HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019805HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RNASEH2A
  • Uniprot No.：
  • 别名：
    RNASEH2A; RNASEHI; RNHIA; Ribonuclease H2 subunit A; RNase H2 subunit A; EC 3.1.26.4; Aicardi-Goutieres syndrome 4 protein; AGS4; RNase H(35); Ribonuclease HI large subunit; RNase HI large subunit; Ribonuclease HI subunit A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-299
  • 氨基酸序列
    MDLSELERDN TGRCRLSSPV PAVCRKEPCV LGVDEAGRGP VLGPMVYAIC YCPLPRLADL EALKVADSKT LLESERERLF AKMEDTDFVG WALDVLSPNL ISTSMLGRVK YNLNSLSHDT ATGLIQYALD QGVNVTQVFV DTVGMPETYQ ARLQQSFPGI EVTVKAKADA LYPVVSAASI CAKVARDQAV KKWQFVEKLQ DLDTDYGSGY PNDPKTKAWL KEHVEPVFGF PQFVRFSWRT AQTILEKEAE DVIWEDSASE NQEGLRKITS YFLNEGSQAR PRSSHRYFLE RGLESATSL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
  • 基因功能参考文献：
    1. The expression levels of RNASEH2A, CDK1, and CD151 and their combination could predict the survival of renal cell carcinoma patients. PMID: 29843367
    2. RNaseH2A may be involved in human gliomagenesis. PMID: 27176716
    3. This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2A in patients with Aicardi-Goutieres Syndrome. PMID: 27643693
    4. RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner. PMID: 24986920
    5. Studies indicate that most antiviral-defense systems involve RNase H-like enzymes destroying invading nucleic acids, RNA, or DNA. PMID: 25703292
    6. study identified two synonymous variants in RNASEH2A that result in loss of RNase H2 enzyme function and the consequent Aicardi-Goutieres syndrome phenotype PMID: 23592335
    7. analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome PMID: 21454563

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  • 相关疾病：
    Aicardi-Goutieres syndrome 4 (AGS4)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RNase HII family, Eukaryotic subfamily
  • 数据库链接：

    HGNC: 18518

    OMIM: 606034

    KEGG: hsa:10535

    STRING: 9606.ENSP00000221486

    UniGene: Hs.532851