RCAN1 Antibody

1. A novel mutation of g.482G>T in RCAN1 may be related to congenital heart diseases by causing overexpression of RCAN1. PMID: 28993896
2. RCAN1.4 plays a novel role in regulating endothelial cell migration by establishing endothelial cell polarity in response to VEGF. PMID: 28271280
3. Lycopene inhibits RCAN1-mediated apoptosis by reducing ROS levels and by inhibiting NF-kappaB activation, Nucling induction, and the increase in apoptotic indices in neuronal cells. PMID: 27928873
4. Overexpression of RCAN1 markedly reduced glioma cells viability. PMID: 28061453
5. RCAN1.4 prevents cell proliferation, migration, and invasion in vitro; overexpressed RCAN1.4 in HCC cells prevents growth, angiogenesis, and metastases of xenograft tumors by inhibiting calcineurin activity and nuclear translocation of NFAT1. PMID: 28583823
6. elucidated a novel function of regulator of calcineurin 1 isoform 1 in mitochondria and provides a molecular basis for the regulator of calcineurin 1 isoform over-expression-induced mitochondrial dysfunctions and neuronal apoptosis PMID: 27861892
7. our research revealed that RCAN1 was involved in the development of small cell lung cancer, and it might be a cancer-inhibiting gene for the formation of bone metastases in small cell lung cancer PMID: 28631570
8. The results of the study indicate that RCAN1 is suppressed in endothelial cells of chronically inflamed periodontal tissues. During an acute infection, however, rcan1 seems to be upregulated in endothelial cells, indicating a modulating role in immune homeostasis of periodontal tissues. PMID: 27403036
9. mRNA expression levels of DSCR1 and VEGF-C, and microvessel density are increased in cancerous tissues, compared with paracancerous tissue in hypopharyngeal cancer. PMID: 27922696
10. The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD) susceptibility. PMID: 26569438
11. Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease PMID: 26497675
12. RCAN1 can interact with IkappaBalpha and affect the phosphorylation of IkappaBalpha at tyrosine 42. PMID: 26492364
13. The sequence variations in RCAN1 promoter are not major genetic factors involved in sporadic CHD, at least in the current research population. PMID: 25863471
14. For DSCR1rs6517239, patients with an AA genotype had higher recurrence probability than patients carrying at least one allele G (37 +/- 4% SE vs. 15 +/- 6% SE) (HR: 0.51; 95% CI, 0.27-0.94; P = 0.027). PMID: 25379721
15. E4BP4 and BIM regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1 PMID: 26102033
16. The transcriptional regulation of RCAN1.1 and RCAN1.4 by two alternative promoters, is reported. PMID: 24751678
17. Rcan1-1L may play a protective role in Ang II-treated cardiomyocytes through the induction of mitochondrial autophagy, and may be an alternative method of cardiac protection. PMID: 25978972
18. Results show that Rcan1 isoform 1L (Rcan1-1L) overexpression specifically activates mitophagy and increases cell survival under hypoxic conditions. PMID: 25377251
19. Data show that after IL-1beta treatment, the levels of reactive oxygen species and interleukin 8 (IL-8) mRNA of Down syndrome candidate region-1 (DSCR1)-transfected cells treated without BAPTA was significantly lower than those in pcDNA-transfected cells. PMID: 25218171
20. Study showed that RCAN1 further contributes to Alzheimer's disease pathogenesis by increasing N-glycosylation and Abeta production PMID: 24720891
21. These results suggest that USP22 positively regulates RCAN1 levels, which would consequently affect diverse RCAN1-linked cellular processes. PMID: 25546086
22. results suggest the presence of a novel phosphorylation site in RCAN1 and that its phosphorylation influences calcineurin-dependent inflammatory target gene expression PMID: 25753203
23. HDAC3, a new binding regulator of RCAN1, affects the protein stability and intracellular localization of RCAN1. PMID: 25144594
24. This study demonstrates that increasing RCAN1 expression alters mitochondrial function and increases the susceptibility of neurons to oxidative stress in mammalian cells. PMID: 25009690
25. RCAC1 cellular gene transcription was found to be regulated by NF-kappaB. PMID: 24359503
26. Data indicate that neuron from Down syndrome candidate region 1 (DSCR1)-transgenic mice were more resistant than wild-type neurons to apoptotic cell death following 24 h of glucose deprivation. PMID: 23144708
27. RCAN1 therefore facilitates T cell development and function, and when overexpressed, may contribute to immune dysfunction in Down syndrome. PMID: 23644448
28. The resulte of this study demonistrated that RCAN1 isoform 4 effects may contribute to at least some of the observed phenotypes in individuals with Down syndrome and Alzheimer's. PMID: 23317802
29. These findings suggest that up-regulation of RCAN1 expression followed by activation of the CREB pathway is required in GC-induced apoptosis. PMID: 23185487
30. study found Kaposi's sarcoma herpesvirus K15 protein recruits PLCgamma1, and thereby activates Calcineurin/NFAT1-dependent RCAN1 expression which results in formation of angiogenic tubes PMID: 23028325
31. a new regulatory mechanism of RCAN1 function PMID: 23118980
32. results defined the regulatory mechanism underlying RCAN1 expression and the roles of RCAN1.1 in oxidative stress-induced neurodegeneration in AD and DS pathogenesis PMID: 23038757
33. DSCR1 is a novel regulator of FMRP and Fragile X syndrome and Down syndrome may share disturbances in common pathways that regulate dendritic spine morphology and local protein synthesis PMID: 22863780
34. DSCR1 gene has an important role in the occurrence and development process of laryngopharynx squamous cell carcinoma, and can influence the biological behavior of tumors. PMID: 22256743
35. Co-immunoprecipitation/immunoblot analyses showed that STAT2 enhanced RCAN1 ubiquitination through the ubiquitin E3 ligase FBW7. PMID: 22426484
36. This study suggested that upregulation of RCAN1 may be a valuable biomarker for AD risk. PMID: 21876249
37. these data provide the first evidence that PKA acts as an important regulatory component in the control of RCAN1 function through phosphorylation. PMID: 22293192
38. a direct link between Dyrk1A and RCAN1 in the Caln-NFAT signaling and Tau hyperphosphorylation pathways PMID: 21965663
39. This article proposed that the mechanism by which stress can lead to neurodegeneration involves the inhibition of calcineurin and the induction of GSK-3beta by RCAN1 proteins. PMID: 21680892
40. DSCR1-1L, regulated by a different promoter than DSCR1-4, activates NFAT and its proangiogenic activity is inhibited by cyclosporin. PMID: 17114339
41. TEF3 mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells PMID: 18840614
42. Regulator of calcineurin 1 (RCAN1) gene is a regulator on the activity of calcineurin and was reported to be overexpressed in Alzheimer's disease. PMID: 21838211
43. RCAN1 regulated the calcineurin-NFAT signaling network in a dose-dependent manner. PMID: 21172821
44. Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation. PMID: 21216952
45. Two distinct protein motifs in the C-terminal domain of RCAN1 are involved in binding to calcineurin and calcineurin inhibition PMID: 19332797
46. The RCAN1 protein isoforms are phosphorylated proteins PMID: 12809556
47. RCAN1 interacts with the catalytic subunit (calcineurin A) of the phosphatase calcineurin PMID: 10861295
48. DSCR1 overexpression attenuates NFAT transcriptional activity in vascular smooth muscle cells. PMID: 19926569
49. This study investigated the expression of IL-11 and role of prostaglandin F(2alpha)-F-prostanoid receptor (FP receptor) signaling in the modulation of IL-11 expression in endometrial adenocarcinoma cells. PMID: 20008143
50. DSCR1-1S isoform positively modulates IL-1R-mediated signaling pathways by regulating Tollip/IRAK-1/TRAF6 complex formation. PMID: 19716405

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HGNC: 3040

OMIM: 602917

KEGG: hsa:1827

STRING: 9606.ENSP00000320768

UniGene: Hs.282326