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  4. Recombinant Human Calcipressin-1 (RCAN1)

Recombinant Human Calcipressin-1 (RCAN1)

  • 货号：
    CSB-YP019500HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019500HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019500HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019500HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019500HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Adapt 78; Adapt78; Calcipressin 1; Calcipressin-1; Calcium and oxidant inducible mRNA; CSP 1; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC 1; DSC1; DSCR 1; DSCR1; MCIP 1; MCIP1; Modulatory calcineurin interacting protein 1; Myocyte enriched calcineurin interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; Near DSCR proline rich protein; RCAN1; RCAN1_HUMAN; RCN 1; RCN1; Regulator of calcineurin 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length of isoform 2
  • 表达区域：
    1-197
  • 氨基酸序列
    MEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
  • 基因功能参考文献：
    1. A novel mutation of g.482G>T in RCAN1 may be related to congenital heart diseases by causing overexpression of RCAN1. PMID: 28993896
    2. RCAN1.4 plays a novel role in regulating endothelial cell migration by establishing endothelial cell polarity in response to VEGF. PMID: 28271280
    3. Lycopene inhibits RCAN1-mediated apoptosis by reducing ROS levels and by inhibiting NF-kappaB activation, Nucling induction, and the increase in apoptotic indices in neuronal cells. PMID: 27928873
    4. Overexpression of RCAN1 markedly reduced glioma cells viability. PMID: 28061453
    5. RCAN1.4 prevents cell proliferation, migration, and invasion in vitro; overexpressed RCAN1.4 in HCC cells prevents growth, angiogenesis, and metastases of xenograft tumors by inhibiting calcineurin activity and nuclear translocation of NFAT1. PMID: 28583823
    6. elucidated a novel function of regulator of calcineurin 1 isoform 1 in mitochondria and provides a molecular basis for the regulator of calcineurin 1 isoform over-expression-induced mitochondrial dysfunctions and neuronal apoptosis PMID: 27861892
    7. our research revealed that RCAN1 was involved in the development of small cell lung cancer, and it might be a cancer-inhibiting gene for the formation of bone metastases in small cell lung cancer PMID: 28631570
    8. The results of the study indicate that RCAN1 is suppressed in endothelial cells of chronically inflamed periodontal tissues. During an acute infection, however, rcan1 seems to be upregulated in endothelial cells, indicating a modulating role in immune homeostasis of periodontal tissues. PMID: 27403036
    9. mRNA expression levels of DSCR1 and VEGF-C, and microvessel density are increased in cancerous tissues, compared with paracancerous tissue in hypopharyngeal cancer. PMID: 27922696
    10. The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD) susceptibility. PMID: 26569438
    11. Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease PMID: 26497675
    12. RCAN1 can interact with IkappaBalpha and affect the phosphorylation of IkappaBalpha at tyrosine 42. PMID: 26492364
    13. The sequence variations in RCAN1 promoter are not major genetic factors involved in sporadic CHD, at least in the current research population. PMID: 25863471
    14. For DSCR1rs6517239, patients with an AA genotype had higher recurrence probability than patients carrying at least one allele G (37 +/- 4% SE vs. 15 +/- 6% SE) (HR: 0.51; 95% CI, 0.27-0.94; P = 0.027). PMID: 25379721
    15. E4BP4 and BIM regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1 PMID: 26102033
    16. The transcriptional regulation of RCAN1.1 and RCAN1.4 by two alternative promoters, is reported. PMID: 24751678
    17. Rcan1-1L may play a protective role in Ang II-treated cardiomyocytes through the induction of mitochondrial autophagy, and may be an alternative method of cardiac protection. PMID: 25978972
    18. Results show that Rcan1 isoform 1L (Rcan1-1L) overexpression specifically activates mitophagy and increases cell survival under hypoxic conditions. PMID: 25377251
    19. Data show that after IL-1beta treatment, the levels of reactive oxygen species and interleukin 8 (IL-8) mRNA of Down syndrome candidate region-1 (DSCR1)-transfected cells treated without BAPTA was significantly lower than those in pcDNA-transfected cells. PMID: 25218171
    20. Study showed that RCAN1 further contributes to Alzheimer's disease pathogenesis by increasing N-glycosylation and Abeta production PMID: 24720891
    21. These results suggest that USP22 positively regulates RCAN1 levels, which would consequently affect diverse RCAN1-linked cellular processes. PMID: 25546086
    22. results suggest the presence of a novel phosphorylation site in RCAN1 and that its phosphorylation influences calcineurin-dependent inflammatory target gene expression PMID: 25753203
    23. HDAC3, a new binding regulator of RCAN1, affects the protein stability and intracellular localization of RCAN1. PMID: 25144594
    24. This study demonstrates that increasing RCAN1 expression alters mitochondrial function and increases the susceptibility of neurons to oxidative stress in mammalian cells. PMID: 25009690
    25. RCAC1 cellular gene transcription was found to be regulated by NF-kappaB. PMID: 24359503
    26. Data indicate that neuron from Down syndrome candidate region 1 (DSCR1)-transgenic mice were more resistant than wild-type neurons to apoptotic cell death following 24 h of glucose deprivation. PMID: 23144708
    27. RCAN1 therefore facilitates T cell development and function, and when overexpressed, may contribute to immune dysfunction in Down syndrome. PMID: 23644448
    28. The resulte of this study demonistrated that RCAN1 isoform 4 effects may contribute to at least some of the observed phenotypes in individuals with Down syndrome and Alzheimer's. PMID: 23317802
    29. These findings suggest that up-regulation of RCAN1 expression followed by activation of the CREB pathway is required in GC-induced apoptosis. PMID: 23185487
    30. study found Kaposi's sarcoma herpesvirus K15 protein recruits PLCgamma1, and thereby activates Calcineurin/NFAT1-dependent RCAN1 expression which results in formation of angiogenic tubes PMID: 23028325
    31. a new regulatory mechanism of RCAN1 function PMID: 23118980
    32. results defined the regulatory mechanism underlying RCAN1 expression and the roles of RCAN1.1 in oxidative stress-induced neurodegeneration in AD and DS pathogenesis PMID: 23038757
    33. DSCR1 is a novel regulator of FMRP and Fragile X syndrome and Down syndrome may share disturbances in common pathways that regulate dendritic spine morphology and local protein synthesis PMID: 22863780
    34. DSCR1 gene has an important role in the occurrence and development process of laryngopharynx squamous cell carcinoma, and can influence the biological behavior of tumors. PMID: 22256743
    35. Co-immunoprecipitation/immunoblot analyses showed that STAT2 enhanced RCAN1 ubiquitination through the ubiquitin E3 ligase FBW7. PMID: 22426484
    36. This study suggested that upregulation of RCAN1 may be a valuable biomarker for AD risk. PMID: 21876249
    37. these data provide the first evidence that PKA acts as an important regulatory component in the control of RCAN1 function through phosphorylation. PMID: 22293192
    38. a direct link between Dyrk1A and RCAN1 in the Caln-NFAT signaling and Tau hyperphosphorylation pathways PMID: 21965663
    39. This article proposed that the mechanism by which stress can lead to neurodegeneration involves the inhibition of calcineurin and the induction of GSK-3beta by RCAN1 proteins. PMID: 21680892
    40. DSCR1-1L, regulated by a different promoter than DSCR1-4, activates NFAT and its proangiogenic activity is inhibited by cyclosporin. PMID: 17114339
    41. TEF3 mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells PMID: 18840614
    42. Regulator of calcineurin 1 (RCAN1) gene is a regulator on the activity of calcineurin and was reported to be overexpressed in Alzheimer's disease. PMID: 21838211
    43. RCAN1 regulated the calcineurin-NFAT signaling network in a dose-dependent manner. PMID: 21172821
    44. Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation. PMID: 21216952
    45. Two distinct protein motifs in the C-terminal domain of RCAN1 are involved in binding to calcineurin and calcineurin inhibition PMID: 19332797
    46. The RCAN1 protein isoforms are phosphorylated proteins PMID: 12809556
    47. RCAN1 interacts with the catalytic subunit (calcineurin A) of the phosphatase calcineurin PMID: 10861295
    48. DSCR1 overexpression attenuates NFAT transcriptional activity in vascular smooth muscle cells. PMID: 19926569
    49. This study investigated the expression of IL-11 and role of prostaglandin F(2alpha)-F-prostanoid receptor (FP receptor) signaling in the modulation of IL-11 expression in endometrial adenocarcinoma cells. PMID: 20008143
    50. DSCR1-1S isoform positively modulates IL-1R-mediated signaling pathways by regulating Tollip/IRAK-1/TRAF6 complex formation. PMID: 19716405

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  • 蛋白家族：
    RCAN family
  • 组织特异性：
    Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
  • 数据库链接：

    HGNC: 3040

    OMIM: 602917

    KEGG: hsa:1827

    STRING: 9606.ENSP00000320768

    UniGene: Hs.282326