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Phospho-PKMYT1 (Ser83) Antibody

  • 货号：
    CSB-PA729561
  • 规格：
    ￥2454
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MYT1 (Phospho-Ser83) antibody (left)or the same antibody preincubated with blocking peptide (right).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PKMYT1 Polyclonal antibody
  • Uniprot No.：
    Q99640
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence around phosphorylation site of Serine 83(R-V-S(p)-F-R) derived from Human MYT1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
  • 基因功能参考文献：
    1. Study found that PKMYT1 was essential for the proliferation and mobility of CRC cells in vitro. Also, results demonstrated that patients expressing high level of PKMYT1 displayed a worse overall survival rate than those with a low level of PKMYT1. These data indicated that PKMYT1 was a biomarker for the prediction of the prognosis of the disease. PMID: 29658598
    2. PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition of hepatocellular carcinoma cells PMID: 28648520
    3. Myt1 is inactivated by MEK1 mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis. PMID: 23241949
    4. MYT1 binds to TSAP6 in tumor cells and has a role in cell cycle regulation PMID: 12606722
    5. Myt1 is phosphorylated by polo-like kinase 1 PMID: 12738781
    6. overexpressed during the S phase of the cell cycle compared with the G0/1 phase PMID: 16476973
    7. The results show that Myt1-mediated suppression of Cdc2 activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis in Hela cells. PMID: 18378775

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
  • 数据库链接：

    HGNC: 29650

    OMIM: 602474

    KEGG: hsa:9088

    STRING: 9606.ENSP00000262300

    UniGene: Hs.732385