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PKMYT1 Antibody

  • 货号：
    CSB-PA16029A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA16029A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA16029A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PKMYT1 Polyclonal antibody
  • Uniprot No.：
    Q99640
  • 基因名：
  • 别名：
    cdc2 inhibitory kinase antibody; DKFZp547K1610 antibody; FLJ20093 antibody; Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase antibody; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase antibody; MYT1 antibody; Myt1 kinase antibody; PKMYT 1 antibody; Pkmyt1 antibody; PMYT1_HUMAN antibody; PPP1R126 antibody; Protein kinase membrane associated tyrosine/threonine 1 antibody; Protein kinase Myt1 antibody; Protein phosphatase 1 regulatory subunit 126 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase protein (900-1101AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PKMYT1 Antibody (CSB-PA16029A0Rb)，的标记方式是Non-conjugated。对于PKMYT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA16029B0Rb PKMYT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA16029C0Rb PKMYT1 Antibody, FITC conjugated
    Biotin CSB-PA16029D0Rb PKMYT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
  • 基因功能参考文献：
    1. Study found that PKMYT1 was essential for the proliferation and mobility of CRC cells in vitro. Also, results demonstrated that patients expressing high level of PKMYT1 displayed a worse overall survival rate than those with a low level of PKMYT1. These data indicated that PKMYT1 was a biomarker for the prediction of the prognosis of the disease. PMID: 29658598
    2. PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition of hepatocellular carcinoma cells PMID: 28648520
    3. Myt1 is inactivated by MEK1 mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis. PMID: 23241949
    4. MYT1 binds to TSAP6 in tumor cells and has a role in cell cycle regulation PMID: 12606722
    5. Myt1 is phosphorylated by polo-like kinase 1 PMID: 12738781
    6. overexpressed during the S phase of the cell cycle compared with the G0/1 phase PMID: 16476973
    7. The results show that Myt1-mediated suppression of Cdc2 activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis in Hela cells. PMID: 18378775

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
  • 数据库链接：

    HGNC: 29650

    OMIM: 602474

    KEGG: hsa:9088

    STRING: 9606.ENSP00000262300

    UniGene: Hs.732385