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PSMA7 Antibody

  • 货号：
    CSB-PA01335A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PSMA7 antibody at 2µg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 28, 21, 17 kDa
      Observed band size: 28 kDa
    • Western blot
      All lanes: PSMA7 antibody at 1.6 µg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: Mouse liver tissue
      Lane 3: Mouse kidney tissue
      Lane 4: Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 28, 21, 17 kDa
      Observed band size: 28 kDa
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA01335A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA01335A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA01335A0Rb at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA01335A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PSMA7 Polyclonal antibody
  • Uniprot No.：
    O14818
  • 基因名：
    PSMA7
  • 别名：
    C6 antibody; HSPC antibody; MGC3755 antibody; OTTHUMP00000031449 antibody; OTTHUMP00000031450 antibody; OTTHUMP00000031453 antibody; Proteasome (prosome macropain) subunit alpha type 7 antibody; Proteasome alpha 7 subunit antibody; Proteasome subunit alpha 4 antibody; Proteasome subunit alpha type 7 antibody; Proteasome subunit alpha type-7 antibody; Proteasome subunit RC6 1 antibody; Proteasome subunit RC6-1 antibody; Proteasome subunit XAPC7 antibody; PSA7_HUMAN antibody; PSMA 7 antibody; PSMA7 antibody; RC6 1 antibody; XAPC7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Proteasome subunit alpha type-7 protein (5-232AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PSMA7 Antibody (CSB-PA01335A0Rb)，的标记方式是Non-conjugated。对于PSMA7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA01335B0Rb PSMA7 Antibody, HRP conjugated ELISA
    FITC CSB-PA01335C0Rb PSMA7 Antibody, FITC conjugated
    Biotin CSB-PA01335D0Rb PSMA7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
  • 基因功能参考文献：
    1. salivary exosomal PSMA7 was present at high levels in salivary exosomes from subjects with Inflammatory bowel disease. It can be a very promising biomarker PMID: 28523434
    2. Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit 9 (PSMD9), proteasome alpha type 7 subunit (PSMA7) and PSMD13 genes. PMID: 26624926
    3. c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit PMID: 25620702
    4. PSMA7 functions partially through downregulation NOD1. PMID: 23839082
    5. PSMA7 inhibits the proliferation, tumorigenicity and invasion of A549 cells in vitro PMID: 22584585
    6. High expression of PSMA7 was significantly correlated with liver metastasis. PMID: 19062718
    7. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha4) subunit at Tyr-153. PMID: 16678104
    8. PSMA7 may play an important role in colorectal cancer progression. PMID: 18202793
    9. cell surface binding of EMAP-II results in its internalization into the cytoplasmic compartment where it interacts with PSMA7, a component of the proteasome degradation pathway. This interaction increases HIF-1alpha degradation under hypoxic conditions. PMID: 19362550

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1A family
  • 数据库链接：

    HGNC: 9536

    OMIM: 606607

    KEGG: hsa:5688

    STRING: 9606.ENSP00000359910

    UniGene: Hs.233952