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PSMA7 Antibody

  • 中文名称：
    PSMA7兔多克隆抗体
  • 货号：
    CSB-PA018873GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14818
  • 基因名：
    PSMA7
  • 别名：
    C6 antibody; HSPC antibody; MGC3755 antibody; OTTHUMP00000031449 antibody; OTTHUMP00000031450 antibody; OTTHUMP00000031453 antibody; Proteasome (prosome macropain) subunit alpha type 7 antibody; Proteasome alpha 7 subunit antibody; Proteasome subunit alpha 4 antibody; Proteasome subunit alpha type 7 antibody; Proteasome subunit alpha type-7 antibody; Proteasome subunit RC6 1 antibody; Proteasome subunit RC6-1 antibody; Proteasome subunit XAPC7 antibody; PSA7_HUMAN antibody; PSMA 7 antibody; PSMA7 antibody; RC6 1 antibody; XAPC7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PSMA7
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
  • 基因功能参考文献：
    1. salivary exosomal PSMA7 was present at high levels in salivary exosomes from subjects with Inflammatory bowel disease. It can be a very promising biomarker PMID: 28523434
    2. Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit 9 (PSMD9), proteasome alpha type 7 subunit (PSMA7) and PSMD13 genes. PMID: 26624926
    3. c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit PMID: 25620702
    4. PSMA7 functions partially through downregulation NOD1. PMID: 23839082
    5. PSMA7 inhibits the proliferation, tumorigenicity and invasion of A549 cells in vitro PMID: 22584585
    6. High expression of PSMA7 was significantly correlated with liver metastasis. PMID: 19062718
    7. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha4) subunit at Tyr-153. PMID: 16678104
    8. PSMA7 may play an important role in colorectal cancer progression. PMID: 18202793
    9. cell surface binding of EMAP-II results in its internalization into the cytoplasmic compartment where it interacts with PSMA7, a component of the proteasome degradation pathway. This interaction increases HIF-1alpha degradation under hypoxic conditions. PMID: 19362550

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1A family
  • 数据库链接：

    HGNC: 9536

    OMIM: 606607

    KEGG: hsa:5688

    STRING: 9606.ENSP00000359910

    UniGene: Hs.233952