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PPM1H Antibody

  • 货号：
    CSB-PA892345LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA892345LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA892345LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA892345LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse stomach tissue, Mouse kidney tissue, Mouse skeletal muscle tissue
      All lanes: PPM1H antibody at 3.2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 57 kDa
      Observed band size: 57 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPM1H Polyclonal antibody
  • Uniprot No.：
    Q9ULR3
  • 基因名：
    PPM1H
  • 别名：
    PPM1H antibody; ARHCL1 antibody; KIAA1157 antibody; URCC2 antibody; Protein phosphatase 1H antibody; EC 3.1.3.16 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Protein phosphatase 1H protein (73-289AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PPM1H Antibody (CSB-PA892345LA01HU)，的标记方式是Non-conjugated。对于PPM1H Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892345LB01HU PPM1H Antibody, HRP conjugated ELISA
    FITC CSB-PA892345LC01HU PPM1H Antibody, FITC conjugated
    Biotin CSB-PA892345LD01HU PPM1H Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:10000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
  • 基因功能参考文献：
    1. PPM1H may be a new tumor-suppressor factor for pancreatic cancer and provides new insight into molecular targets for gene therapy of pancreatic cancer PMID: 27599670
    2. PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins. PMID: 24732009
    3. Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27. PMID: 22586611
    4. PPM1H, overexpressed in colon adenocarcinoma, is associated with CSE1L protein. PMID: 18059182
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    PP2C family
  • 数据库链接：

    HGNC: 18583

    OMIM: 616016

    KEGG: hsa:57460

    UniGene: Hs.435479