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  4. Recombinant Human Protein phosphatase 1H (PPM1H)

Recombinant Human Protein phosphatase 1H (PPM1H)

  • 中文名称：
    人PPM1H重组蛋白
  • 货号：
    CSB-YP892345HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PPM1H重组蛋白
  • 货号：
    CSB-EP892345HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PPM1H重组蛋白
  • 货号：
    CSB-EP892345HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PPM1H重组蛋白
  • 货号：
    CSB-BP892345HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PPM1H重组蛋白
  • 货号：
    CSB-MP892345HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PPM1H
  • Uniprot No.：
  • 别名：
    PPM1H; ARHCL1; KIAA1157; URCC2; Protein phosphatase 1H; EC 3.1.3.16
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-514
  • 氨基酸序列
    MLTRVKSAVA NFMGGIMAGS SGSEHGGGSC GGSDLPLRFP YGRPEFLGLS QDEVECSADH IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV LTVKKKAGAV TSTPNRNSSK RRSSLPNGEG LQLKENSESE GVSCHYWSLF DGHAGSGAAV VASRLLQHHI TEQLQDIVDI LKNSAVLPPT CLGEEPENTP ANSRTLTRAA SLRGGVGAPG SPSTPPTRFF TEKKIPHECL VIGALESAFK EMDLQIERER SSYNISGGCT ALIVICLLGK LYVANAGDSR AIIIRNGEII PMSSEFTPET ERQRLQYLAF MQPHLLGNEF THLEFPRRVQ RKELGKKMLY RDFNMTGWAY KTIEDEDLKF PLIYGEGKKA RVMATIGVTR GLGDHDLKVH DSNIYIKPFL SSAPEVRIYD LSKYDHGSDD VLILATDGLW DVLSNEEVAE AITQFLPNCD PDDPHRYTLA AQDLVMRARG VLKDRGWRIS NDRLGSGDDI SVYVIPLIHG NKLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
  • 基因功能参考文献：
    1. PPM1H may be a new tumor-suppressor factor for pancreatic cancer and provides new insight into molecular targets for gene therapy of pancreatic cancer PMID: 27599670
    2. PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins. PMID: 24732009
    3. Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27. PMID: 22586611
    4. PPM1H, overexpressed in colon adenocarcinoma, is associated with CSE1L protein. PMID: 18059182
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    PP2C family
  • 数据库链接：

    HGNC: 18583

    OMIM: 616016

    KEGG: hsa:57460

    UniGene: Hs.435479