PLEKHA8 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) PLEKHA8 Polyclonal antibody
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Uniprot No.:Q96JA3
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基因名:PLEKHA8
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别名:FAPP-2 antibody; FAPP2 antibody; hFAPP2 antibody; MGC3358 antibody; PH domain-containing family A member 8 antibody; Phosphatidylinositol-four-phosphate adapter protein 2 antibody; Phosphoinositide binding specificmember 8 antibody; Phosphoinositol 4 phosphate adaptor protein 2 antibody; Phosphoinositol 4-phosphate adapter protein 2 antibody; PKHA8_HUMAN antibody; Pleckstrin homology domain containing A8 antibody; Pleckstrin homology domain containing family A (Phosphoinositide binding specific) member 8 antibody; Pleckstrin homology domain containing family A antibody; Pleckstrin homology domain-containing family A member 8 antibody; Plekha8 antibody; PLEKHA8 protein antibody; Serologically defined breast cancer antigen NY-BR-86 antibody
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宿主:Rabbit
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反应种属:Human, Mouse
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免疫原:Recombinant Human Pleckstrin homology domain-containing family A member 8 protein (1-300AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,PLEKHA8 Antibody (CSB-PA856957LA01HU),的标记方式是Non-conjugated。对于PLEKHA8 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to th...显示更多
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基因功能参考文献:
- Altogether, this study implies that hepatitis C virus coopts FAPP2 for virus genome replication via phosphatidylinositol 4-phosphate binding and glycosphingolipid transport to the hepatitis C virus replication complex. PMID: 25122779
- FAPP2 functions in both membrane trafficking and lipid metabolism in a fashion that integrates its activities in membrane trafficking and in lipid transfer. (Review) PMID: 22266015
- Data demonstrate FAPP2 is required for cilium formation in polarized MDCK cells. PMID: 17116893
- Data show that FAPP2 is present in tubules forming from the trans-Golgi in epithelial MDCK cells. PMID: 19940249
- FAPP2 plays a specific role in apical transport in MDCK cells. PMID: 16103222
- by coupling the synthesis of glycosphingolipids with their export to the cell surface, FAPP2 emerges as crucial in determining the lipid identity and composition of the plasma membrane PMID: 17687330
- These data demonstrate a previously unknown role for FAPP2 in conferring resistance to apoptosis and indicate that FAPP2 may be a target for cancer therapy. PMID: 19341712
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亚细胞定位:Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein.
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组织特异性:Expressed in kidney cell lines.
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数据库链接:
HGNC: 30037
OMIM: 608639
KEGG: hsa:84725
STRING: 9606.ENSP00000397947
UniGene: Hs.233495