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PLEKHA8 Antibody

  • 货号：
    CSB-PA018162GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96JA3
  • 基因名：
    PLEKHA8
  • 别名：
    FAPP-2 antibody; FAPP2 antibody; hFAPP2 antibody; MGC3358 antibody; PH domain-containing family A member 8 antibody; Phosphatidylinositol-four-phosphate adapter protein 2 antibody; Phosphoinositide binding specificmember 8 antibody; Phosphoinositol 4 phosphate adaptor protein 2 antibody; Phosphoinositol 4-phosphate adapter protein 2 antibody; PKHA8_HUMAN antibody; Pleckstrin homology domain containing A8 antibody; Pleckstrin homology domain containing family A (Phosphoinositide binding specific) member 8 antibody; Pleckstrin homology domain containing family A antibody; Pleckstrin homology domain-containing family A member 8 antibody; Plekha8 antibody; PLEKHA8 protein antibody; Serologically defined breast cancer antigen NY-BR-86 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PLEKHA8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
  • 基因功能参考文献：
    1. Altogether, this study implies that hepatitis C virus coopts FAPP2 for virus genome replication via phosphatidylinositol 4-phosphate binding and glycosphingolipid transport to the hepatitis C virus replication complex. PMID: 25122779
    2. FAPP2 functions in both membrane trafficking and lipid metabolism in a fashion that integrates its activities in membrane trafficking and in lipid transfer. (Review) PMID: 22266015
    3. Data demonstrate FAPP2 is required for cilium formation in polarized MDCK cells. PMID: 17116893
    4. Data show that FAPP2 is present in tubules forming from the trans-Golgi in epithelial MDCK cells. PMID: 19940249
    5. FAPP2 plays a specific role in apical transport in MDCK cells. PMID: 16103222
    6. by coupling the synthesis of glycosphingolipids with their export to the cell surface, FAPP2 emerges as crucial in determining the lipid identity and composition of the plasma membrane PMID: 17687330
    7. These data demonstrate a previously unknown role for FAPP2 in conferring resistance to apoptosis and indicate that FAPP2 may be a target for cancer therapy. PMID: 19341712

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein.
  • 组织特异性：
    Expressed in kidney cell lines.
  • 数据库链接：

    HGNC: 30037

    OMIM: 608639

    KEGG: hsa:84725

    STRING: 9606.ENSP00000397947

    UniGene: Hs.233495