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PLD6 Antibody

  • 货号：
    CSB-PA836649LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA836649LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA836649LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse kidney tissue, Mouse brain tissue, Mouse skeletal muscle tissue
      All lanes: PLD6 antibody at 2.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 29 kDa
      Observed band size: 29 kDa
  • 其他：

产品详情

  • 产品描述：

    The recombinant human mitochondrial cardiolipin hydrolase protein (1-252aa) was inoculated into a rabbit to elicit an immune response leading to the production of antibodies against PLD6. The PLD6 polyclonal antibody was isolated and purified from the rabbit's serum through protein G affinity chromatography. Its purity exceeds 95%. This rabbit anti-human PLD6 polyclonal antibody was tested in the ELISA, WB, IHC and IF. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It reacts with the PLD6 proteins of human or mouse-origin and may be used to detect the endogenous levels of PLD6 protein.

    The target protein PLD6 plays a role in RNA metabolism, specifically in the regulation of alternative splicing and the stability of mRNA. It is also involved in the DNA damage response and autophagy modulation.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PLD6 Polyclonal antibody
  • Uniprot No.：
    Q8N2A8
  • 基因名：
    PLD6
  • 别名：
    Choline phosphatase 6 antibody; Mitochondrial cardiolipin hydrolase antibody; Mitochondrial phospholipase antibody; MitoPLD antibody; Phosphatidylcholine hydrolyzing phospholipase D6 antibody; Phosphatidylcholine-hydrolyzing phospholipase D6 antibody; Phospholipase D family member 6 antibody; Phospholipase D6 antibody; PLD 6 antibody; pld6 antibody; PLD6_HUMAN antibody; Protein zucchini homolog antibody; ZUC antibody; Zucchini, Drosophila, homolog of antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Mitochondrial cardiolipin hydrolase protein (1-252AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PLD6 Antibody (CSB-PA836649LA01HU)，的标记方式是Non-conjugated。对于PLD6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836649LB01HU PLD6 Antibody, HRP conjugated ELISA
    FITC CSB-PA836649LC01HU PLD6 Antibody, FITC conjugated
    Biotin CSB-PA836649LD01HU PLD6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid. Production of PA facilitates Mitofusin-mediated fusion, whereas the cleav...显示更多
  • 基因功能参考文献：
    1. Propose that MIGA proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD. PMID: 26711011
    2. MitoPLD performs a critical function in a pathway that creates a specialized form of RNAi required by developing spermatocytes to suppress transposon mobilization during meiosis. PMID: 22281006
    3. Data suggest that mitochondrial-surface phosphatidic acid generated by MitoPLD/Zuc recruits or activates nuage components critical for piRNA production. PMID: 21397848
    4. PLD6, aka MitoPLD, encodes an N-terminal mitochondrial localization sequence, localizes to the outer mitochondrial surface, generates phosphatidic acid, a signaling lipid, and triggers trans-mitochondrial association; involved in mitochondrial fusion. PMID: 17028579
  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein. Golgi apparatus.
  • 蛋白家族：
    Phospholipase D family, MitoPLD/Zucchini subfamily
  • 组织特异性：
    Predominantly expressed in testis and ovary, but not limited to gonads (at protein level). It is also found in brain, heart, pituitary gland, prostate, pancreas, thyroid, bone marrow, lung and muscle.
  • 数据库链接：

    HGNC: 30447

    OMIM: 614960

    KEGG: hsa:201164

    STRING: 9606.ENSP00000317177

    UniGene: Hs.729079