Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. PLA1A Antibody

PLA1A Antibody

  • 货号：
    CSB-PA020287
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 3T3 cells using PLA1A Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q53H76
  • 基因名：
  • 别名：
    AA986889 antibody; NMD antibody; OTTHUMP00000215248 antibody; OTTHUMP00000215249 antibody; OTTHUMP00000215250 antibody; Phosphatidylserine specific phospholipase A1 antibody; Phosphatidylserine specific phospholipase A1alpha antibody; Phosphatidylserine-specific phospholipase A1 antibody; Phospholipase A1 member A antibody; pla1a antibody; PLA1A_HUMAN antibody; PS PLA1 antibody; PS-PLA1 antibody; PSPLA 1 antibody; PSPLA1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human PLA1A.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling. Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein.; Hydrolyzes lyso-PS but not PS.
  • 基因功能参考文献：
    1. Serum PS-PLA1 levels were significantly higher in the melanoma subjects and associated with the clinical stages. PMID: 29500864
    2. the LysoPA levels might be determined largely by LysoPC and LysoPI (possible precursors) and the PS-PLA1-mediated pathway might be involved in the production of LysoPS in gastric cancer. PMID: 28143894
    3. PS-PLA1 expression in colorectal cancer is associated with tumor invasion and metastasis. PMID: 25750298
    4. These data suggest that PLA1A plays an important role in bridging the membrane-associated NS2-E2 complex and the NS5A-associated replication complex via its interaction with hepatitis C virus E2, NS2, and NS5A. PMID: 25505071
    5. PLA1A2 polymorphism is associated with mortality in participants whose hemoglobin A1c ranges from 5.5% to 6.5%. PMID: 24886443
    6. Overall, our study shed the light on new structural features of the phospholipase activity of pancreatic lipase family members. PMID: 24368210
    7. These results suggest that the expression of PS-PLA(1) mRNA in THP-1-derived macrophages is activated via TLR4. PMID: 20573295
    8. polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 PMID: 12436198

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    AB hydrolase superfamily, Lipase family
  • 组织特异性：
    Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
  • 数据库链接：

    HGNC: 17661

    OMIM: 607460

    KEGG: hsa:51365

    STRING: 9606.ENSP00000273371

    UniGene: Hs.437451