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OSR1 Antibody

  • 中文名称：
    OSR1兔多克隆抗体
  • 货号：
    CSB-PA017262GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TAX0
  • 基因名：
    OSR1
  • 别名：
    OSR1 antibody; ODD antibody; Protein odd-skipped-related 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human OSR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.
  • 基因功能参考文献：
    1. Kir2.1 and Kir2.3, are activated by OSR1 through a motif variant, R-x-F-x-V/I. PMID: 29581290
    2. Odd-skipped related 1 (OSR1) downregulated the activity of the Wnt signaling pathway by suppressing the expression of sex-determining region Y-box 9 (SOX9) and beta-catenin. PMID: 29660200
    3. OSR1 was downregulated in RCC cells by promoter methylation. OSR1 can function as a tumor suppressor via inhibition of invasion and proliferation in RCC cells, possibly via upregulating tumor suppressor genes and downregulating oncogenes. PMID: 28404905
    4. OSR1 was sequenced in 186 children with primary vesicoureteric reflux, and 17 have single nucleotide polymorphisms PMID: 28724605
    5. In summary, our study implicated a gene network involving Tbx5, Osr1 and Pcsk6 interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 in congenital heart disease ontogeny. PMID: 26744331
    6. The findings of the present study showed, for the first time, the role of the OSR1 rs12329305 polymorphism in the development of congenital malformations in cases of stillborn/neonatal death. PMID: 25164089
    7. OSR1 acts as a functional tumour suppressor in gastric cancer PMID: 24931004
    8. OSR1 is expressed in human mesenchymal stem cells, the blastemal component of Wilms tumors and CD24+/CD133+ progenitor cells isolated from the mature kidney. PMID: 21821672
    9. first report on molecular cloning and characterization of human OSR1 PMID: 12119563

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Odd C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in adult colon, small intestine, prostate, testis, and fetal lung.
  • 数据库链接：

    HGNC: 8111

    OMIM: 608891

    KEGG: hsa:130497

    STRING: 9606.ENSP00000272223

    UniGene: Hs.123933