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  4. Recombinant Human Protein odd-skipped-related 1 (OSR1)

Recombinant Human Protein odd-skipped-related 1 (OSR1)

  • 中文名称：
    人OSR1重组蛋白
  • 货号：
    CSB-YP855038HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人OSR1重组蛋白
  • 货号：
    CSB-EP855038HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人OSR1重组蛋白
  • 货号：
    CSB-EP855038HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人OSR1重组蛋白
  • 货号：
    CSB-BP855038HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人OSR1重组蛋白
  • 货号：
    CSB-MP855038HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    OSR1
  • Uniprot No.：
  • 别名：
    OSR1; ODD; Protein odd-skipped-related 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-266
  • 氨基酸序列
    MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP AMHLPRSSFS KVPGTVSSLV DARFQLPAFP WFPHVIQPKP EITAGGSVPA LKTKPRFDFA NLALAATQED PAKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK TLHSQVKELK TSKIKC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.
  • 基因功能参考文献：
    1. Kir2.1 and Kir2.3, are activated by OSR1 through a motif variant, R-x-F-x-V/I. PMID: 29581290
    2. Odd-skipped related 1 (OSR1) downregulated the activity of the Wnt signaling pathway by suppressing the expression of sex-determining region Y-box 9 (SOX9) and beta-catenin. PMID: 29660200
    3. OSR1 was downregulated in RCC cells by promoter methylation. OSR1 can function as a tumor suppressor via inhibition of invasion and proliferation in RCC cells, possibly via upregulating tumor suppressor genes and downregulating oncogenes. PMID: 28404905
    4. OSR1 was sequenced in 186 children with primary vesicoureteric reflux, and 17 have single nucleotide polymorphisms PMID: 28724605
    5. In summary, our study implicated a gene network involving Tbx5, Osr1 and Pcsk6 interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 in congenital heart disease ontogeny. PMID: 26744331
    6. The findings of the present study showed, for the first time, the role of the OSR1 rs12329305 polymorphism in the development of congenital malformations in cases of stillborn/neonatal death. PMID: 25164089
    7. OSR1 acts as a functional tumour suppressor in gastric cancer PMID: 24931004
    8. OSR1 is expressed in human mesenchymal stem cells, the blastemal component of Wilms tumors and CD24+/CD133+ progenitor cells isolated from the mature kidney. PMID: 21821672
    9. first report on molecular cloning and characterization of human OSR1 PMID: 12119563

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Odd C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in adult colon, small intestine, prostate, testis, and fetal lung.
  • 数据库链接：

    HGNC: 8111

    OMIM: 608891

    KEGG: hsa:130497

    STRING: 9606.ENSP00000272223

    UniGene: Hs.123933