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  4. ORC2 Antibody

ORC2 Antibody

  • 货号：
    CSB-PA017232GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q13416
  • 基因名：
  • 别名：
    orc2 antibody; ORC2_HUMAN antibody; ORC2L antibody; Origin of replication 2 (yeast homolog) like antibody; Origin recognition complex protein 2 homolog antibody; Origin recognition complex subunit 2 antibody; Origin recognition complex subunit 2 isoform B antibody; Origin recognition complex subunit 2 like (yeast) antibody; Origin recognition complex, subunit 2 homolog antibody; Origin recognition complex, subunit 2, S. cerevisiae, homolog of antibody; Origin recognition complex, subunit 2-like (S. cerevisiae) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ORC2L
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.
  • 基因功能参考文献：
    1. the ORC2 complex with E2 restricts viral replication in the maintenance phase of the viral replication program PMID: 27701460
    2. ORC2 SUMOylation promotes recruitment of KDM5A to centromeres. PMID: 27052177
    3. Protein phosphatase 1 dephosphorylates Orc2 to promote the binding of ORC to chromatin and replication origins for the subsequent round of the cell cycle. PMID: 24792176
    4. These results suggest that PP1 dephosphorylates Orc2 to promote the binding of ORC to chromatin. PMID: 24732362
    5. Gemcitabine resistance is dependent on Plk1-mediated phosphorylation of Orc2 and Hbo1. PMID: 23188630
    6. Orc2 protects ORCA from ubiquitin-mediated degradation in vivo. PMID: 22935713
    7. The phosphorylation of ORC2 dissociates origin recognition complex (ORC) from chromatin and replication origins and inhibits binding of ORC to newly replicated DNA. PMID: 22334659
    8. Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress PMID: 21947279
    9. the human origin recognition complex has a role in sequence-independent DNA binding and replication initiation PMID: 12897055
    10. The precise nucleotide of binding for ORC2 was identified near the stgart site for leading-strand synthesis; the transition to the post-replicative complex is accompanied by a 17 bp displacement of ORC2 towards the start site. PMID: 12912926
    11. Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that human Ku80 and Orc2 bind to replication origins independently of each other. PMID: 15910003
    12. The low level of Orc2 in Orc2 hypomorphic cells hinders normal cell cycle progression by delaying the activation of G1 cyclin-dependent kinases. PMID: 16407251
    13. human Orc2 has specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex PMID: 16762929

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ORC2 family
  • 数据库链接：

    HGNC: 8488

    OMIM: 601182

    KEGG: hsa:4999

    STRING: 9606.ENSP00000234296

    UniGene: Hs.444870