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NGEF Antibody

  • 货号：
    CSB-PA850809LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of PC-3 cells with CSB-PA850809LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NGEF Polyclonal antibody
  • Uniprot No.：
    Q8N5V2
  • 基因名：
    NGEF
  • 别名：
    ARHGEF27 antibody; Eph receptor-interacting exchange protein antibody; Eph-interacting exchange protein antibody; EPHEXIN antibody; Ephexin-1 antibody; Guanine nucleotide exchange factor, neuronal antibody; Neuronal guanine nucleotide exchange factor antibody; Ngef antibody; NGEF_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ephexin-1 protein (495-710AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NGEF Antibody (CSB-PA850809LA01HU)，的标记方式是Non-conjugated。对于NGEF Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850809LB01HU NGEF Antibody, HRP conjugated ELISA
    FITC CSB-PA850809LC01HU NGEF Antibody, FITC conjugated
    Biotin CSB-PA850809LD01HU NGEF Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
  • 基因功能参考文献：
    1. A visceral-fat-associated SNP, rs11678490 of NGEF, was found in Korean men. PMID: 26340433
    2. FGFR-mediated phosphorylation of ephexin1 enhances the guanine nucleotide exchange activity toward RhoA without affecting the activity to Rac1 or Cdc42. PMID: 17702745
  • 亚细胞定位：
    Cytoplasm. Membrane. Cell projection, growth cone.
  • 组织特异性：
    Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.
  • 数据库链接：

    HGNC: 7807

    OMIM: 605991

    KEGG: hsa:25791

    STRING: 9606.ENSP00000264051

    UniGene: Hs.97316